Prophylactic human papillomavirus vaccines: will they do their job?
Article first published online: 9 NOV 2009
© 2010 Blackwell Publishing Ltd
Journal of Internal Medicine
Volume 267, Issue 3, pages 251–259, March 2010
How to Cite
Stanley, M. (2010), Prophylactic human papillomavirus vaccines: will they do their job?. Journal of Internal Medicine, 267: 251–259. doi: 10.1111/j.1365-2796.2009.02193.x
- Issue published online: 1 FEB 2010
- Article first published online: 9 NOV 2009
- cervical carcinoma;
- neutralizing antibody;
- prophylactic vaccines
Abstract. Stanley M (University of Cambridge, Cambridge, UK). Prophylactic HPV vaccines: will they do their job? (Foresight). J Intern Med 2010; 267: 251–259
The prophylactic HPV L1 virus like particle vaccines are highly efficacious preventing >98% of HPV 16/18 caused high grade cervical intra-epithelial neoplasia (CIN2/3) according to protocol group in phase III randomized clinical trials over approximately 4 years. Data from the trials together with postvaccine surveillance indicates that they have a good safety profile. As the current HPV vaccines include only two of the 15 oncogenic HPVs, they will not eliminate cervical cancer or the other HPV associated ano-genital diseases but could reduce, for example, the incidence of cervix cancer by up to 70–80%, if effectively delivered to adolescent females.