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- Blocking IL-1 in rheumatoid arthritis
- Classic autoinflammatory diseases
- Type 2 diabetes, a chronic, low-grade autoinflammatory disease
- Recurrent attacks of gout
- Is smouldering myeloma an autoinflammatory disease?
- Conflict of interest statement
Abstract. Dinarello CA (Department of Medicine, University of Colorado, Aurora, CO, USA). Blocking interleukin-1β in acute and chronic autoinflammatory diseases. (Key Symposium) J Intern Med 2011; 269: 16–28.
An expanding spectrum of acute and chronic inflammatory diseases is considered ‘autoinflammatory’ diseases. This review considers autoinflammatory diseases as being distinct from ‘autoimmune’ diseases. Autoimmune diseases are associated with dysfunctional T cells and treated with ‘biologicals’, including antitumour necrosis factorα, CTLA-Ig, anti-IL-12/23, anti-CD20, anti-IL-17 and anti-IL-6 receptor. In contrast, autoinflammatory diseases are uniquely attributed to a dysfunctional monocyte caspase 1 activity and secretion of IL-1β; indeed, blocking IL-1β results in a rapid and sustained reduction in the severity of most autoinflammatory diseases. Flares of gout, type 2 diabetes, heart failure and smouldering multiple myeloma are examples of seemingly unrelated diseases, which are uniquely responsive to IL 1β neutralization.