The metabolic syndrome: time to get off the merry-go-round?
Version of Record online: 3 DEC 2010
© 2010 The Association for the Publication of the Journal of Internal Medicine
Journal of Internal Medicine
Volume 269, Issue 2, pages 127–136, February 2011
How to Cite
Reaven, G. M. (2011), The metabolic syndrome: time to get off the merry-go-round?. Journal of Internal Medicine, 269: 127–136. doi: 10.1111/j.1365-2796.2010.02325.x
- Issue online: 11 JAN 2011
- Version of Record online: 3 DEC 2010
- Accepted manuscript online: 15 NOV 2010 10:41AM EST
- cardiovascular disease;
- insulin resistance;
- metabolic syndrome;
- type 2 diabetes
Abstract. Reaven GM (Stanford University School of Medicine). The metabolic syndrome: time to get off the merry-go-round? (Review) J Intern Med 2011; 269: 127–136.
The diagnostic category of the metabolic syndrome (MetS) has received considerable attention over the last decade, and prestigious organizations continue to strive for its incorporation into medical practice. This review has three goals: (i) summarize the history of the several attempts to define a diagnostic category designated as the MetS; (ii) question the aetiological role of abdominal obesity in the development of the other components of the MetS; and (iii) evaluate a diagnosis of the MetS as an effective way to identify apparently healthy individuals at increased risk to develop cardiovascular disease (CVD) or type 2 diabetes (2DM). The most important conclusion is that the MetS seems to be less effective in this population than the Framingham Risk Score in predicting CVD, and no better, if not worse, than fasting plasma glucose concentrations in predicting 2DM.