Maternal and paternal transmission of type 2 diabetes: influence of diet, lifestyle and adiposity
Article first published online: 1 MAR 2011
© 2011 The Association for the Publication of the Journal of Internal Medicine
Journal of Internal Medicine
Volume 270, Issue 4, pages 388–396, October 2011
How to Cite
Abbasi, A., Corpeleijn, E., van der Schouw, Y. T., Stolk, R. P., Spijkerman, A. M. W., van der A, D. L., Navis, G., Bakker, S. J. L. and Beulens, J. W. J. (2011), Maternal and paternal transmission of type 2 diabetes: influence of diet, lifestyle and adiposity. Journal of Internal Medicine, 270: 388–396. doi: 10.1111/j.1365-2796.2011.02347.x
- Issue published online: 19 SEP 2011
- Article first published online: 1 MAR 2011
- Accepted manuscript online: 19 JAN 2011 11:58AM EST
- parental history;
- type 2 diabetes
Abstract. Abbasi A, Corpeleijn E, van der Schouw YT, Stolk RP, Spijkerman AMW, van der A DL, Navis G, Bakker SJL, Beulens JWJ (University Medical Center Groningen, Groningen; University Medical Centre Utrecht, Utrecht; and National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands) Maternal and paternal transmission of type 2 diabetes: influence of diet, lifestyle and adiposity. J Intern Med 2011; 270: 388–396.
Objective. Transmission of family history of type 2 diabetes to the next generation is stronger for maternal than paternal diabetes in some populations. The aim of the present study was to investigate whether this difference is explained by diet, lifestyle factors and/or adiposity.
Methods. We analysed 35 174 participants from the Dutch contribution to the European Prospective Investigation into Cancer and Nutrition, a prospective population-based cohort (aged 20–70 years) with a median follow-up of 10.2 years. Parental history of diabetes was self-reported. Occurrence of diabetes was mainly identified by self-report and verified by medical records.
Results. Amongst 35 174 participants, 799 incident cases of diabetes were observed. In age- and sex-adjusted analyses, hazard ratio (HR) and 95% confidence intervals (CIs) for diabetes by maternal and paternal diabetes were 2.66 (2.26–3.14) and 2.40 (1.91–3.02), respectively. Maternal transmission of risk of diabetes was explained by diet (9.4%), lifestyle factors including smoking, alcohol consumption, physical activity and educational level (7.8%) and by adiposity, i.e. body mass index and waist and hip circumference (23.5%). For paternal transmission, the corresponding values were 2.9%, 0.0% and 9.6%. After adjustment for diet, lifestyle factors and adiposity, the HRs for maternal (2.20; 95% CI, 1.87–2.60) and paternal (2.23; 95% CI, 1.77–2.80) transmission of diabetes were comparable.
Conclusions. Both maternal and paternal diabetes are associated with increased risk of type 2 diabetes, independently of diet, lifestyle and adiposity. The slightly higher risk conferred by maternal compared to paternal diabetes was explained by a larger contribution of diet, lifestyle factors and adiposity.