• 1
    Danesh J, Wheeler JG, Hirschfield GM et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 2004; 350: 138797.
  • 2
    Zairis MN, Adamopoulou EN, Manousakis SJ et al. Biomarkers of Inflammation and Outcome in Acute Coronary Syndromes (BIAS) Investigators. The impact of hsC-reactive protein and other inflammatory biomarkers on long-term cardiovascular mortality in patients with acute coronary syndromes. Atherosclerosis 2007; 194: 397402.
  • 3
    Kannel WB, Anderson K, Wilson PW. White blood cell count and cardiovascular disease. Insights from the Framingham Study. JAMA 1992; 267: 12536.
  • 4
    Margolis KL, Manson JE, Greenland P et al. Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women’s Health Initiative Observational Study. Arch Intern Med 2005; 165: 5008.
  • 5
    Madjid M, Awan I, Willerson JT, Casscells SW. Leukocyte count and coronary heart disease: implications for risk assessment. J Am Coll Cardiol 2004; 44: 194556.
  • 6
    Li C, Engström G, Hedblad B. Leukocyte count is associated with increased coronary events, but not with stroke: a prospective cohort study. Atherosclerosis 2010; 209: 54550.
  • 7
    Persson M, Nilsson J-Å, Nelson JJ, Hedblad B, Berglund G. The epidemiology of Lp-PLA2: distribution and correlation with cardiovascular risk factors in a populations-based cohort. Atherosclerosis 2007; 190: 38896.
  • 8
    Persson M, Hedblad B, Nelson JJ, Berglund G. Elevated Lp-PLA2 levels add prognostic information to the metabolic syndrome on incidence of cardiovascular events among middle-aged nondiabetic subjects. Atheriosler Thromb Vasc Biol 2007; 27: 14116.
  • 9
    Macphee CH, Moores K, Boyd H et al. Lipoprotein-associated phospholipase A2 generates two bioactive products during the oxidation of low density lipoprotein. Studies using a novel inhibitor. Biochem J 1999; 338: 47987.
  • 10
    Koenig W, Twardella D, Brenner H, Rothenbacher D. Lipoprotein-associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stress. Arterioscler Thromb Vasc Biol 2006; 26: 158693.
  • 11
    Oei HH, van der Meer IM, Hofman A et al. Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam Study. Circulation 2005; 111: 5705.
  • 12
    O’Donoghue M, Morrow DA, Sabatine MS et al. Lipoprotein-associated phospholipase A2 and its association with cardiovascular outcomes in patients with acute coronary syndromes in the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction) trial. Circulation 2006; 113: 174552.
  • 13
    Robins SJ, Collins D, Nelson JJ, Bloomfield HE, Asztalos BF. Cardiovascular events with increased lipoprotein-associated phospholipase A(2) and low high-density lipoprotein-cholesterol: the Veterans Affairs HDL Intervention Trial. Arterioscler Thromb Vasc Biol 2008; 28: 11728.
  • 14
    Hatoum IJ, Hu FB, Nelson JJ, Rimm EB. Lipoprotein-associated phospholipase A2 activity and incident coronary heart disease among men and women with type 2 diabetes. Diabetes 2010; 59: 123943.
  • 15
    Mente A, de Koning L, Shannon HS, Anand SS. A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch Intern Med 2009; 169: 65969.
  • 16
    Wirfält E, Mattisson I, Gullberg B, Berglund G. Food patterns defined by cluster analysis and their utility as dietary exposure variables: a report from the Malmö Diet and Cancer Study. Public Health Nutr 1999; 3: 15973.
  • 17
    Wirfält E, Hedblad B, Gullberg B et al. Food patterns and components of the metabolic syndrome in men and women: a cross-sectional study within the Malmö Diet and Cancer Cohort. Am J Epidemiol 2001; 154: 11509.
  • 18
    Tzotzas T, Filippatos TD, Triantos A, Bruckert E, Tselepis AD, Kiortsis DN. Effects of low-calorie diet associated with weight loss on lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in healthy obese women. Nutr Metab Cardiovasc Dis 2008; 18: 47782.
  • 19
    Chrysohoou C, Panagiotakos DB, Pitsavos C, Das UN, Stefanadis C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: the ATTICA Study. J Am Coll Cardiol 2004; 44: 1528.
  • 20
    Hatoum IJ, Nelson JJ, Cook NR, Hu FB, Rimm EB. Dietary, lifestyle, and clinical predictors of lipoprotein-associated phospholipase A2 activity in individuals without coronary artery disease. Am J Clin Nutr 2010; 91: 78693.
  • 21
    Boynton A, Neuhouser ML, Wener MH et al. Associations between healthy eating patterns and immune function or inflammation in overweight or obese postmenopausal women. Am J Clin Nutr 2007; 86: 144555.
  • 22
    Centritto F, Iacoviello L, di Giuseppe R et al. Dietary patterns, cardiovascular risk factors and C-reactive protein in a healthy Italian population. Nutr Metab Cardiovasc Dis 2009; 19: 697706.
  • 23
    Lopez-Garcia E, Schulze MB, Fung TT et al. Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction. Am J Clin Nutr 2004; 80: 102935.
  • 24
    Berglund G, Elmståhl S, Janzon L et al. The Malmö Diet and Cancer Study: design and feasibility. J Intern Med 1993; 233: 4551.
  • 25
    Elmståhl S, Gullberg B, Riboli E, Saracci R, Lindgarde F. The Malmö Food Study: the reproducibility of a novel diet history method and an extensive food frequency questionnaire. Eur J Clin Nutr 1996; 50: 13442.
  • 26
    Riboli E, Elmståhl S, Saracci R, Gullberg B, Lindgarde F. The Malmö Food Study: validity of two dietary assessment methods for measuring nutrient intake. Int J Epidemiol 1997; 26: 16173.
  • 27
    Elmståhl S, Riboli E, Lindgarde F, Gullberg B, Saracci R. The Malmö Food Study: the relative validity of a modified diet history method and an extensive food frequency questionnaire for measuring food intake. Eur J Clin Nutr 1996; 50: 14351.
  • 28
    Occupations in Population and Housing Census 1985 (FoB 85) According to Nordic Standard Occupational Classification (Nordisk yrkesklassificering, NYK) and Swedish Socio-economic Classification (Socioekonomisk indelning SEI). Reports on Statistical co-ordination 1989:5. Stockholm, Sweden: Statistics Sweden, 1989 (in Swedish).
  • 29
    Taylor HL, Jacobs Jr DR, Schucker B, Knudsen J, Leon AS, Debacker G. A questionnaire for the assessment of leisure time physical activities. J Chronic Dis 1978; 31: 74155.
  • 30
    Richardson M, Leon A, Jacobs Jr D et al. Comprehensive evaluation of the Minnesota Leisure Time Physical Activity Questionnaire. J Clin Epidemiol 1994; 47: 27181.
  • 31
    Friedewald WT, Levy RI, Fredrickson DS. Estimation of concentration of low-density lipoprotein cholesterol in plasma, without use of preparative ultra centrifuge. Clin Chem 1971; 18: 499502.
  • 32
    The National board of Health and Welfare. Värdering av diagnoskvaliteten för akut hjärtinfarkt i patientregistret 1997 och 1995 (in Swedish). Stockholm, Sweden: Socialstyrelsen, 2000.
  • 33
    Jerntorp P, Berglund G. Stroke registry in Malmö. Stroke 1992; 23: 35761.
  • 34
    National Board of Health and Welfare, Center of Epidemiology. The Validity of the Acute Myocardial Infarction in the Patient Registry 1987 and 1995. Stockholm, Sweden: National Board of Health and Welfare, Center of Epidemiology, 2000.
  • 35
    Shi Y, Zhang P, Zhang L et al. Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses. Atherosclerosis 2007; 191: 5462.
  • 36
    Zalewski A, Macphee C. Role of lipoprotein-associated phospholipase A2 in atherosclerosis: biology, epidemiology, and possible therapeutic target. Arterioscler Thromb Vasc Biol 2005; 25: 92331.
  • 37
    Packard CJ, O’Reilly DS, Caslake MJ et al. Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group. N Engl J Med 2000; 19: 343.
  • 38
    Brilakis ES, McConnell JP, Lennon RJ, Elesber AA, Meyer JG, Berger PB. Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk factors, angiographic coronary artery disease, and major adverse events at follow-up. Eur Heart J 2005; 26: 13744.
  • 39
    Koenig W, Khuseyinova N, Löwel H, Trischler G, Meisinger C. Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C-reactive protein in apparently healthy middle-aged men from the general population: results from the 14-year follow-up of a large cohort from southern Germany. Circulation 2004; 5: 110.
  • 40
    Elkind MS, Tai W, Coates K, Paik MC, Sacco RL. High-sensitivity C-reactive protein, lipoprotein-associated phospholipase A2, and outcome after ischemic stroke. Arch Intern Med 2006; 166: 207380.
  • 41
    Beulens JWJ, van den Berg R, Kok FJ, Helander A, Vermunt SHF, Hendriks HFJ. Moderate alcohol consumption and lipoprotein-associated A2 activity. Nutr Metab Cardiovasc Dis 2008; 18: 53944.
  • 42
    Barclay AW, Petocz P, McMillan-Price J et al. Glycemic index, glycemic load, and chronic disease risk-a meta-analysis of observation studier. Am J Clin Nutr 2008; 87: 62737.
  • 43
    Pedersen MW, Koenig W, Christensen JH, Schmidt EB. The effect of marine n-3 fatty acids in different doses on plasma concentrations of Lp-PLA2 in healthy adults. Eur J Nutr 2009; 48: 15.
  • 44
    Jacobi J, Sela S, Cohen HI, Chezar J, Kristal B. Priming of polymorphonuclear leukocytes: a culprit in the initiation of endothelial cell injury. Am J Physiol Heart Circ Physiol 2006; 290: H20518.
  • 45
    Moriguchi S, Hamada M, Yamauchi K, Sakai K, Yamamoto S. The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging. J Med Invest 1998; 45: 18.
  • 46
    Hall JA, Wander RC, Gradin JL, Du SH, Jewell DE. Effect of dietary n_6-to-n_3 fatty acid ratio on complete blood and total white blood cell counts, and T-cell subpopulations in aged dogs. Am J Vet Res 1999; 60: 31927.
  • 47
    Fung TT, Rimm EB, Spiegelman D et al. Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk. Am J Clin Nutr 2001; 73: 617.
  • 48
    Nettleton JA, Steffen LM, Mayer-Davis EJ et al. Dietary patterns are associated with biochemical markers of inflammation and endothelial activation in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr 2006; 83: 136979.
  • 49
    Sonestedt E, Gullberg B, Elisabet Wirfält E. Both food habit change in the past and obesity status may influence the association between dietary factors and postmenopausal breast cancer. Public Health Nutr 2007; 10: 76979.
  • 50
    Manjer J, Carlsson S, Elmståhl S et al. The Malmö Diet and Cancer Study: representativity, cancer incidence and mortality in participants and non-participants. Eur J Cancer Prev 2001; 10: 48999.