Hepatitis C and autoimmunity: a therapeutic challenge
Article first published online: 12 MAY 2011
© 2011 The Association for the Publication of the Journal of Internal Medicine
Journal of Internal Medicine
Volume 271, Issue 1, pages 104–106, January 2012
How to Cite
Böckle, B. C., Baltaci, M., Ratzinger, G., Graziadei, I., Vogel, W. and Sepp, N. T. (2012), Hepatitis C and autoimmunity: a therapeutic challenge. Journal of Internal Medicine, 271: 104–106. doi: 10.1111/j.1365-2796.2011.02391.x
- Issue published online: 16 DEC 2011
- Article first published online: 12 MAY 2011
- Accepted manuscript online: 19 APR 2011 09:36AM EST
- B-cell clone;
- hepatitis C;
- lupus erythematosus;
Abstract. Böckle BC, Baltaci M, Ratzinger G, Graziadei I, Vogel W, Sepp NT (Innsbruck Medical University, Anichstrasse, Innsbruck, Austria). Hepatitis C and autoimmunity: a therapeutic challenge (Case Report). J Intern Med 2012; 271: 104–106.
Hepatitis C virus (HCV) infection causes not only acute and chronic liver disease, but also extrahepatic symptoms. To our knowledge, this is the first case report of a patient who developed simultaneously subacute cutaneous lupus erythematosus and a small CD20+ B-cell clone because of chronic HCV infection and relapse after standard of care therapy (pegylated interferon plus ribavirin). Treatment with rituximab, a chimeric anti-CD20 monoclonal antibody, was successful.