Letter to the Editor
Screening for hepatocellular carcinoma in acute intermittent porphyria
Article first published online: 26 JUL 2011
© 2011 The Association for the Publication of the Journal of Internal Medicine
Journal of Internal Medicine
Volume 270, Issue 4, page 398, October 2011
How to Cite
Wiwanitkit, V. (2011), Screening for hepatocellular carcinoma in acute intermittent porphyria. Journal of Internal Medicine, 270: 398. doi: 10.1111/j.1365-2796.2011.02425.x
- Issue published online: 19 SEP 2011
- Article first published online: 26 JUL 2011
- Accepted manuscript online: 5 JUL 2011 05:49AM EST
I read the recent publication on screening for hepatocellular carcinoma (HCC) in acute intermittent porphyria with great interest . Innala and Andersson  concluded that ‘Screening for HCC in carriers of AIP enables early diagnosis and a choice of potentially curative treatments with improved prognosis’ and also recommended ‘annual screening using liver imaging for AIP gene carriers >50 years of age’. There are some concerns regarding this long-term study. First, there are many other confounding causes of liver cancer such as alcohol and viral infection with hepatitis. The effect of these possible confounding factors should be clarified and controlled for. Second, it would be interesting to know the cost-effectiveness of the proposed screening. Population-scale screening might not be wise if the benefit is low compared with the cost.
Conflict of interest statement
No conflict of interest was declared.