Immune activation and increased IL-21R expression are associated with the loss of memory B cells during HIV-1 infection
Version of Record online: 15 JUN 2012
© 2012 The Association for the Publication of the Journal of Internal Medicine
Journal of Internal Medicine
Volume 272, Issue 5, pages 492–503, November 2012
How to Cite
Ruffin, N., Lantto, R., Pensieroso, S., Sammicheli, S., Hejdeman, B., Rethi, B. and Chiodi, F. (2012), Immune activation and increased IL-21R expression are associated with the loss of memory B cells during HIV-1 infection. Journal of Internal Medicine, 272: 492–503. doi: 10.1111/j.1365-2796.2012.02550.x
- Issue online: 22 OCT 2012
- Version of Record online: 15 JUN 2012
- Accepted manuscript online: 24 APR 2012 10:04AM EST
Figure S1. B cell phenotype during HIV-1 infection.
Figure S2. Plasma IL-21 levels are decreased during HIV-1 infection.
Figure S3. Percentages of CD38 expression in total, naïve, classical (CD27+) memory, resting memory (RM’), activated memory (AM) and tissue-like memory (TLM) B cells were correlated with CD4 T cell counts (A and B) and HIV-1 viraemia (C) measured in total HIV-1-infected patients (n = 40, A) and patients naïve to treatment (n = 20, B and C).
Figure S4. Plasma levels of LPS are correlated with IL-21R in RM B cells.
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