Cadmium exposure is accompanied by increased prevalence and future growth of atherosclerotic plaques in 64-year-old women
Version of Record online: 20 AUG 2012
© 2012 The Association for the Publication of the Journal of Internal Medicine
Journal of Internal Medicine
Volume 272, Issue 6, pages 601–610, December 2012
How to Cite
Cadmium exposure is accompanied by increased prevalence and future growth of atherosclerotic plaques in 64-year-old women. J Intern Med 2012; doi: 10.1111/j.1365-2796.2012.02578.x., , , Sahlgrenska University Hospital, Gothenburg; University of Gothenburg, Gothenburg; and Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden
- Issue online: 20 NOV 2012
- Version of Record online: 20 AUG 2012
- Accepted manuscript online: 20 JUL 2012 12:44AM EST
- Swedish Research Council
- Swedish Heart-Lung Foundation
- Swedish Foundation for Strategic Research and AstraZeneca R&D Mölndal
- cardiovascular risk factors;
- carotid artery;
There is currently widespread exposure to the toxic metal cadmium through the diet as well as through smoking, and it has been suggested that cadmium exposure may increase the risk of cardiovascular disease. Here we examined whether cadmium exposure is associated with prevalence and growth of atherosclerotic plaques in the carotid arteries.
Design and subjects
The analyses were performed in a screening-based cohort of 64-year-old Caucasian women with stratified, random selection to groups with normal glucose tolerance, impaired glucose tolerance and diabetes (n = 599). We measured cadmium concentrations in blood and urine at baseline. In addition, we performed ultrasound examination to determine the prevalence and area of atherosclerotic plaques in the carotid arteries and assessed smoking history and other cardiovascular risk factors at baseline and at a follow-up examination after a mean of 5.4 years.
At baseline, blood cadmium levels were associated with increased risk of plaque and a large plaque area after adjustment for confounders. In women who had never smoked, blood cadmium levels correlated positively with plaque area at baseline. The occurrence of large plaques and the change in plaque area at follow-up were associated with blood and creatinine-corrected urinary cadmium concentrations at baseline after adjustment for confounders. Blood and urine cadmium levels added information to established cardiovascular risk factors in predicting progress of atherosclerosis.
We have shown that cadmium levels in blood and urine are independent factors associated with the development of atherosclerotic plaques at baseline as well as prospectively. This novel observation emphasizes the need to consider cadmium as a pro-atherogenic pollutant.