Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process


M. Stevanović. Tel: +381-11-2636-994; Fax: +381-11-2185-263; e-mail: magir@eunet.yu


Poly(dl-lactide-co-glycolide) powder composed of uniform particles with the mean particle size in the range of 110–170 nm was obtained from commercial granules. Ascorbic acid in different concentrations was encapsulated into the poly(dl-lactide-co-glycolide) particles. Degradation of the latter in terms of morphological changes in the physiological solution was followed. Within a period of 2 months, the particles completely degrade and all the ascorbic acid is released. The samples were characterized by ultraviolet spectroscopy and scanning electron microscopy.