This article is dedicated to Bob Gleaser.
Cryo-EM—the first thirty years
Article first published online: 15 NOV 2011
© 2011 The Author Journal of Microscopy © 2011 Royal Microscopical Society
Journal of Microscopy
Volume 245, Issue 3, pages 221–224, March 2012
How to Cite
DUBOCHET, J. (2012), Cryo-EM—the first thirty years. Journal of Microscopy, 245: 221–224. doi: 10.1111/j.1365-2818.2011.03569.x
- Issue published online: 20 FEB 2012
- Article first published online: 15 NOV 2011
- Received 2 July 2011; accepted 11 October 2011
- Cryo-electron microscopy;
- Vitreous section;
Thirty years ago, in December 1981, The Journal of Microscopy published a very short paper entitled ‘Vitrification of pure water for electron microscopy’. It turned out to be important for the development of cryo-electron microscopy and it contributed to reverse, from foe to friend, the status of water in electron microscopists’ minds. This change has brought obvious gains. The future will tell how many more are still to come.