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Apelin and Vasopressin: Two Work Better than One


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All communications to the editor
Prof. Mike Ludwig
Centre for Integrative Physiology
University of Edinburgh
Edinburgh EH8 9XD, UK


Water retention in the kidney is known to be an active phenomenon, controlled by a neuropeptide: vasopressin. Water excretion was assumed to be a passive phenomenon, as a result of vasopressin release blockade. This simplistic view is incorrect because water excretion is also controlled by a diuretic neuropeptide, apelin, produced not only by several peripheral tissues, but also by hypothalamic neurones, in particular the vasopressin ones projecting to the posterior pituitary.