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Interaction of Sex Steroid Hormones and Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Signalling: Relevance to Schizophrenia and Depression


  • R. A. Hill

    Corresponding author
    1. Centre for Neuroscience, University of Melbourne, Melbourne, Australia
    • Behavioural Neuroscience Laboratory, Mental Health Research Institute, Melbourne, Australia
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Correspondence to: R. A. Hill, Mental Health Research Institute, University of Melbourne, Kenneth Myer Building, At Genetics Lane on Royal Parade, Parkville, Victoria 3010, Australia (e-mail:


Sex steroid hormones and neurotrophic factors are involved in pruning and shaping the developing brain and have been implicated in the pathogenesis of neurodevelopmental disorders. Sex steroid hormones are also involved in the regulation of brain-derived neurotrophic factor expression. A review of the literature is provided on the relationship between brain-derived neurotrophic factor and sex steroid hormones, as well as the mechanisms behind this interaction, in the context of how this relationship may be involved in the development of neurodevelopmental psychiatric illnesses, such as schizophrenia and depression.

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