Efficacy of alpha lipoic acid in burning mouth syndrome: a randomized, placebo-treatment study


Dr Pía López-Jornet, Clínica Odontológica Universitaria, Medicina Bucal Hospital Morales Meseguer, Adv. Marques de los Velez s/n, Murcia 30008, Spain. E-mail: majornet@um.es


Summary  To study the efficacy of alpha lipoic acid (ALA) in a group of patients with burning mouth syndrome (BMS). Sixty BMS patients, 30 treated with ALA (Thioderm®) 800 mg day−1 for 8 weeks and 30 patients on the same protocol with a placebo. The symptomatology was measured on a Visual Analogue Scale (VAS). Sixty patients (54 females and 6 males, mean age 64·37 ± 11·61 years) were included. Thirty-nine patients completed the treatment (23 with ALA and 16 with a placebo). Reviews were carried out at 0, 1 and 2 months. No statistically significant differences were found in the average pre- and post-treatment values for pain with the VAS scores, obtained in the placebo (6·6 ± 2·5 − 2·8 ± 25 = 3·8 ± 3·7) versus ALA (6·3 ± 2·8 − 4·0 ± 2·7 = 2·2 ± 2·6). Only one patient pertaining to the group treated with ALA abandoned because of adverse gastrointestinal side effects. The results showed no significant differences between the two groups.