Temazepam at high altitude reduces periodic breathing without impairing next-day performance: a randomized cross-over double-blind study
Article first published online: 17 NOV 2006
Journal of Sleep Research
Volume 15, Issue 4, pages 445–454, December 2006
How to Cite
NICKOL, A. H., LEVERMENT, J., RICHARDS, P., SEAL, P., HARRIS, G. A., CLELAND, J., DUBOWITZ, G., COLLIER, D. J., MILLEDGE, J., STRADLING, J. R. and MORRELL, M. J. (2006), Temazepam at high altitude reduces periodic breathing without impairing next-day performance: a randomized cross-over double-blind study. Journal of Sleep Research, 15: 445–454. doi: 10.1111/j.1365-2869.2006.00558.x
- Issue published online: 17 NOV 2006
- Article first published online: 17 NOV 2006
- Accepted in revised form 20 September 2006; received 10 April 2006
- Operation Everest II: arterial oxygen saturation and sleep at extreme simulated altitude. Am. Rev. Respir. Dis., 1992, 145: 817–826. , , , , , and
- Effects of Zolpidem and Zaleplon on sleep, respiratory patterns and performance at a simulated altitude of 4,000 m. Neuropsychobiology, 2004, 49: 154–162. , , , , , and
- Sleep fragmentation indices as predictors of daytime sleepiness and nCPAP response in obstructive sleep apnoea. Am. J. Respir. Crit. Care Med., 1998, 158: 778–786. , , and
- Hypoxic ventilatory response in successful extreme altitude climbers. Eur. Respir. J., 2006, 27: 165–171. , , , and
- Benzodiazepines in congestive heart failure: effects of temazepam on arousability and Cheyne–Stokes respiration. Sleep, 1993, 16: 529–538. , , and
- Effect of sleep disruption on sleep, performance, and mood. Sleep, 1985, 8: 11–19.
- Performance and sleepiness as a function of frequency and placement of sleep disruption. Psychophysiology, 1986, 23: 263–271.
- The effect of triazolam on arousal and respiration in central sleep apnea patients. Sleep, 1990, 13: 31–41. , and
- Clinical and physiologic heterogeneity of the central sleep apnea syndrome. Am. Rev. Respir. Dis., 1986, 134: 217–221. , , , , and
- Impact of age on breathing and resistive pressure in people with and without sleep apnea. J. Appl. Physiol., 2001, 90: 1074–1082. , , and
- Computerised cognitive assessment of athletes with sports related head injury. Br. J. Sports Med., 2001, 35: 297–302. , and
- A sleep – induced apneic threshold and its consequences. Am. Rev. Respir. Dis., 1986, 133: 1163–1170. and
- Effect of temazepam on oxygen saturation and sleep quality at high altitude: randomised placebo controlled cross over trial. Br. Med. J., 1998, 316: 587–589.
- Comparison of the effects of zolpidem and flunitrazepam on sleep structure and daytime cognitive functions. Pharmacopsychiatry, 1998, 31: 14–18. , , , , and
- The Lake Louise consensus on the definition and qualification of altitude illness. In: J.Sutton, G.Coates and C.Houston (Eds) Hypoxia and mountain medicine. Queen City Press, Burlington, 1992: 327–330. and
- The cost to the central nervous system of climbing to extremely high altitude. N. Eng. J. Med., 1989, 321: 1714–1719. , , , and
- Dynamics of periodic breathing and arousal during sleep at extreme altitude. Respir. Physiol., 1996, 103: 33–43. , , , , , and
- Benzodiazepines and vigilance performance: a review. Psychopharmacology, 1989, 98: 145–156.
- The use of microcomputer-based psychomotor tests for the evaluation of benzodiazepine effects on human performance: a review with emphasis on temazepam. Br. J. Clin. Pharmacol., 1992, 34: 289–301. , , , and
- Dependence of high altitude sleep apnea on ventilatory sensitivity to hypoxia. Respir. Physiol., 1983, 52: 281–301. , and
- Computerised cognitive assessment of concussed Australian Rules footballers. Br. J. Sports Med., 2001, 35: 354–360. , , , , , and
- The ventilatory response to hypoxia: how much is good for a mountaineer? Postgrad. Med. J., 1986, 63: 169–172.
- Hypnotics: clinical pharmacology and therapeutics. In: M. H.Kryger, T.Roth and W. C.Dement (Eds) Principles and Practice of Sleep Medicine. WB Saunders Co, London, 1989: 219–227 .
- Altitude insomnia: studies during an expedition to the Himalayas. Sleep, 1988, 11: 354–361. , , , and
- Correlation between oscillations in ventilation and frequency content of the electroencephalogram. J. Appl. Physiol., 1992, 72: 985–992. , , , and
- Autonomic markers of arousal during sleep in patients undergoing investigation for obstructive sleep apnoea, their relationship to EEG arousals, respiratory events and subjective sleepiness. J. Sleep. Res., 1998, 7: 53–59. and
- Sleep at altitude. Sem. Respir. Med., 1983, 5: 175–180. and
- Microsleep during a simplified maintenance of wakefulness test. Am. J. Respir. Crit. Care Med., 2001, 163: 1619–1625. , , , and
- Sleep physiology at high altitude. Electroencephalogr. Clin. Neurophysiol., 1975, 38: 463–471. , , and
- The role of actigraphy in the evaluation of sleep disorders. Sleep, 1995, 18: 288–302. , , and
- Effects of high-altitude periodic breathing on sleep and arterial oxyhaemoglobin saturation. Eur. Respir. J., 1998, 12: 408–413. , , , , , , , and
- Influence of testosterone on breathing during sleep. J. Appl. Physiol., 1986, 61: 618–623. , , , , , , and
- Relationship of hypoxic ventilatory response to exercise performance on Mount Everest. J. Appl. Phyisol., 1984, 56: 1478–1483. , , , , , , , , , and
- Reversal of central sleep apnea using nasal CPAP. Chest, 1986, 90: 165–171. , and
- Benzoctamine – a study of the respiratroy effects of oral doses in human volunteers and interactions with morphine in mice. Br. J. Anaesthesiol., 1975, 47: 987–992. and
- Nocturnal periodic breathing at altitude of 6,300 and 8,050 m. J. Appl. Physiol., 1986, 61: 280–287. , , , , and