Arousal and Cardiorespiratory Responses
The effect of flow limitation on the cardiorespiratory response to arousal from sleep under controlled conditions of chemostimulation in healthy older adults
Version of Record online: 10 MAY 2012
© 2012 European Sleep Research Society
Journal of Sleep Research
Volume 21, Issue 6, pages 718–723, December 2012
How to Cite
GOFF, E. A., NICHOLAS, C. L., KLEIMAN, J., SPEAR, O., MORRELL, M. J. and TRINDER, J. (2012), The effect of flow limitation on the cardiorespiratory response to arousal from sleep under controlled conditions of chemostimulation in healthy older adults. Journal of Sleep Research, 21: 718–723. doi: 10.1111/j.1365-2869.2012.01019.x
- Issue online: 27 NOV 2012
- Version of Record online: 10 MAY 2012
- Accepted in revised form 1 April 2012; received 19 July 2011
- The acute effects of continuous positive airway pressure and oxygen administration on blood pressure during obstructive sleep apnea. Chest, 1992, 101: 1526–1532. , , and
- Non-Invasive detection of respiratory effort-related arousals (REras) by a nasal cannula/pressure transducer system. Sleep, 2000, 23: 763–771. , , , , and
- Sleep apnoea and daytime function in the elderly – what is the impact of arousal frequency? Respir. Med., 2003, 97: 1102–1108. , , and
- Acute cardiovascular responses to arousal from non-REM sleep during normoxia and hypoxia. Sleep, 2001, 24: 895–902. , , , , and
- Assessment of inspiratory flow limitation invasively and noninvasively during sleep. Am. J. Respir. Crit. Care Med., 1998, 158: 713–722. , , , and
- Flow limitation as a noninvasive assessment of residual upper-airway resistance during continuous positive airway pressure therapy of obstructive sleep apnea. Am. J. Respir. Crit. Care Med., 1994, 150: 475–480. , , , , and
- Arterial blood pressure responses to graded transient arousal from sleep in normal humans. J. Appl. Physiol., 1993, 74: 1123–1130. , , , and
- The upper airway resistance syndrome. Chest, 1999, 115: 1127–1139. and
- Repetive, episodic hypoxia causes diurnal elevation of systemic blood pressure in rats. Hypertension, 1992, 19: 555–561. , , , and
- The cardiovascular response to arousal from sleep decreases with age in healthy adults. Sleep, 2008, 31: 1009–1017. , , , and
- Immediate effects of arousal from sleep on cardaic autonomic outflow in the absence of breathing in dogs. J. Appl. Physiol., 1995, 79: 151–162. , , , and
- Activation of a distinct arousal state immediately after spontaneous awakening from sleep. Brain Res., 1997, 778: 127–134. , , and
- Detection of flow limitation with a nasal cannula/pressure transducer system. Am. J. Respir. Crit. Care Med., 1998, 157: 1461–1467. , , and
- The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans. J. Physiol., 2004a, 558: 993–1004. , , et al.
- CPAP-therapy effectively lowers serum homocysteine in obstructive sleep apnea syndrome. J. Neural Transm., 2004b, 111: 683–689. , , et al.
- Cardiovascular regulatory mechanisms in advanced age. Physiol. Rev., 1993, 73: 413–467.
- Frequency of EEG arousals from nocturnal sleep in normal subjects. Sleep, 1995, 18: 330–333. and
- Neurocirculatory consequences of abrupt change in sleep state in humans. J. Appl. Physiol., 1996, 80: 1627–1636. , , , , and
- Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. JAMA, 2000, 283: 1829–1836. , , et al.
- Airway obstruction during sleep increases blood pressure without arousal. J. Appl. Physiol., 1996, 80: 773–781. , , , , and
- The effect of upper airway obstruction and arousal on peripheral arterial tonometry in obstructive sleep apnea. Am. J. Respir. Crit. Care Med., 2002, 166: 965–971. , , and
- Cardiovascular response to arousal from sleep under controlled conditions of central and peripheral chemoreceptor stimulation in humans. J. Appl. Physiol., 2004, 96: 865–870. , , , and
- Occlusion of the upper airway does not augment the cardiovascular response to arousal from sleep in humans. J. Appl. Physiol., 2005, 98: 1349–1355. , , and
- Prospective study of the association between sleep-disordered breathing and hypertension. N. Engl. J. Med., 2000, 342: 1378–1384. , , and
- Hypoxemia alone does not explain blood pressure elevations after obstructive apneas. J. Appl. Physiol., 1990a, 69: 2143–2148. , , et al.
- Cardiovascular effects of mechanical ventilation. Arch. Dis. Child., 1999, 80: 475–480. and
- Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. EEG arousals: scoring, and examples. A preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep, 1992, 15: 173–184.
- Sympathetic-nerve activity during sleep in normal subjects. N. Engl. J. Med., 1993, 328: 303–307. , , and
- Cardiac and respiratory activity at arousal from sleep under controlled ventilation conditions. J. Appl. Physiol., 2001, 90: 1455–1463. , , et al.
- The cardiorespiratory activation response at an arousal from sleep is independent of the level of CO(2). J. Sleep Res., 2006, 15: 174–182. , , , and