Clinical efficacy of ampicillin, pivampicillin and procaine penicillin G in a soft tissue infection model in ponies

Authors

  • J. M. ENSINK,

    Corresponding author
    1. Department of General and Large Animal Surgery, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
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  • W. R. KLEIN,

    1. Department of General and Large Animal Surgery, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
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  • A. BARNEVELD,

    1. Department of General and Large Animal Surgery, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
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  • A. G. VULTO,

    1. Veterinary Hospital Pharmacy, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
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  • A.S.J.P.A.M. van MIERT

    1. Department of Veterinary Basic Sciences, Division of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
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J.M. Ensink, Department of General and Large Animal Surgery, PO Box 80. 153, 3508 TD Utrecht, The Netherlands.

Abstract

Tissue chambers, implanted subcutaneously in ponies, were inoculated with Streptococcus zooepidemicus. The animals received either no antibiotics or one of the following treatments: pivampicillin per os (19.9 mg/kg, equivalent to 15 mg/kg ampicillin, every 12 h) for 7 or 21 days (7 and 5 ponies, respectively), procaine penicillin G intramuscularly (12 mg/kg = 12,000 IU/kg, every 24 h) for 7 days (7 ponies), or ampicillin sodium intravenously (equivalent to 15 mg/kg ampicillin, every 8 h) for 1 day (5 ponies). Only intravenous administration was started before infection (prophylactically), the other treatments were started 20 h after infection (curatively). A total of 7 ponies received no antibiotics. In untreated controls, the infection led to abscessation of the tissue chamber in 4 to 10 days. Curative treatment with either pivampicillin or procaine penicillin G for 7 days resulted in a reduction of viable bacteria in the tissue chamber but did not eliminate the infection, resulting in abscessation in 5 to 14 days. However, administration of pivampicillin for 21 days eliminated the streptococci in five out of five ponies and prophylactic administration of ampicillin was successful in three out of five ponies.

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