Presented in part at the Annual Meeting of Eurotox, Amsterdam, September 10–12, 2007; American Academy of Veterinary Nutrition, San Antonio, TX, June 3–5, 2008; and IXth World Conference on Clinical Pharmacology and Therapeutics, Quebec City, Canada, July 27–August 1, 2008.
Therapeutic efficacy of undenatured type-II collagen (UC-II) in comparison to glucosamine and chondroitin in arthritic horses1
Version of Record online: 26 APR 2009
© 2009 Blackwell Publishing Ltd
Journal of Veterinary Pharmacology and Therapeutics
Volume 32, Issue 6, pages 577–584, December 2009
How to Cite
GUPTA, R. C., CANERDY, T. D., SKAGGS, P., STOCKER, A., ZYRKOWSKI, G., BURKE, R., WEGFORD, K., GOAD, J. T., ROHDE, K., BARNETT, D., DeWEES, W., BAGCHI, M. and BAGCHI, D. (2009), Therapeutic efficacy of undenatured type-II collagen (UC-II) in comparison to glucosamine and chondroitin in arthritic horses. Journal of Veterinary Pharmacology and Therapeutics, 32: 577–584. doi: 10.1111/j.1365-2885.2009.01079.x
- Issue online: 11 NOV 2009
- Version of Record online: 26 APR 2009
- (Paper received 25 November 2008; accepted for publication 30 March 2009)
The present investigation evaluated arthritic pain in horses receiving daily placebo, undenatured type II collagen (UC-II) at 320, 480, or 640 mg (providing 80, 120, and 160 mg active UC-II, respectively), and glucosamine and chondroitin (5.4 and 1.8 g, respectively, bid for the first month, and thereafter once daily) for 150 days. Horses were evaluated for overall pain, pain upon limb manipulation, physical examination, and liver and kidney functions. Evaluation of overall pain was based upon a consistent observation of all subjects during a walk and a trot in the same pattern on the same surface. Pain upon limb manipulation was conducted after the walk and trot. It consisted of placing the affected joint in severe flexion for a period of 60 sec. The limb was then placed to the ground and the animal trotted off. The response to the flexion test was then noted with the first couple of strides the animal took. Flexion test was consistent with determining clinically the degree of osteoarthritis in a joint. Horses receiving placebo showed no change in arthritic condition, while those receiving 320 or 480 or 640 mg UC-II exhibited significant reduction in arthritic pain (P < 0.05). UC-II at 480 or 640 mg dose provided equal effects, and therefore, 480 mg dose was considered optimal. With this dose, reduction in overall pain was from 5.7 ± 0.42 (100%) to 0.7 ± 0.42 (12%); and in pain upon limb manipulation from 2.35 ± 0.37 (100%) to 0.52 ± 0.18 (22%). Although glucosamine and chondroitin treated group showed significant (P < 0.05) reduction in pain compared with pretreated values, the efficacy was less compared with that observed with UC-II. In fact, UC-II at 480 or 640 mg dose was found to be more effective than glucosamine and chondroitin in arthritic horses. Clinical condition (body weight, body temperature, respiration rate, and pulse rate), and liver (bilirubin, GGT, and ALP) and kidney (BUN and creatinine) functions remained unchanged, suggesting that these supplements were well tolerated.