The authors, except Dr Hyyppä, are employed by the manufacturer of the study drugs.
Bioavailability of detomidine administered sublingually to horses as an oromucosal gel
Version of Record online: 8 JUL 2010
© 2010 Blackwell Publishing Ltd
Journal of Veterinary Pharmacology and Therapeutics
Volume 34, Issue 1, pages 76–81, February 2011
How to Cite
KAUKINEN, H., ASPEGRÉN, J., HYYPPÄ, S., TAMM, L. and SALONEN, J. S. (2011), Bioavailability of detomidine administered sublingually to horses as an oromucosal gel. Journal of Veterinary Pharmacology and Therapeutics, 34: 76–81. doi: 10.1111/j.1365-2885.2010.01193.x
- Issue online: 10 JAN 2011
- Version of Record online: 8 JUL 2010
- (Paper received 30 September 2009; accepted for publication 28 February 2010)
Kaukinen, H., Aspegrén, J., Hyyppä, S., Tamm, L., Salonen, J. S. Bioavailability of detomidine administered sublingually to horses as an oromucosal gel. J. vet. Pharmacol. Therap. 34, 76–81.
The objective of the study was to determine the absorption, bioavailability and sedative effect of detomidine administered to horses as an oromucosal gel compared to intravenous and intramuscular administration of detomidine injectable solution. The study was open and randomized, with three sequences crossover design. Nine healthy horses were given 40 μg/kg detomidine intravenously, intramuscularly or administered under the tongue with a 7-day wash-out period between treatments. Blood samples were collected before and after drug administration for the measurement of detomidine concentrations in serum. The effects of the route of administration on heart rate and rhythm were evaluated and the depth of sedation assessed. Mean (±SD) bioavailability of detomidine was 22% (±5.3%) after sublingual administration and 38.2% (±7.9%) after intramuscular administration. The sedative effects correlated with detomidine concentrations regardless of the route of administration. We conclude that less detomidine is absorbed when given sublingually than when given intramuscularly, because part of it does not reach the circulation. Sublingual administration of detomidine oromucosal gel at 40 μg/kg produces safe sedation in horses. Slow absorption leads to fewer and less pronounced adverse effects than the more rapid absorption after intramuscular injection.