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Patient variation in veterinary medicine – Part II – Influence of physiological variables
Article first published online: 18 NOV 2010
© 2010 Blackwell Publishing Ltd
Journal of Veterinary Pharmacology and Therapeutics
Volume 34, Issue 3, pages 209–223, June 2011
How to Cite
MODRIC, S. and MARTINEZ, M. (2011), Patient variation in veterinary medicine – Part II – Influence of physiological variables. Journal of Veterinary Pharmacology and Therapeutics, 34: 209–223. doi: 10.1111/j.1365-2885.2010.01249.x
- Issue published online: 14 APR 2011
- Article first published online: 18 NOV 2010
- (Paper received 31 January 2009; accepted for publication 18 September 2010)
Modric, S., Martinez, M. Patient variation in veterinary medicine – Part II – Influence of physiological variables. J. vet. Pharmacol. Therap.34, 209–223.
In veterinary medicine, the characterization of a drug’s pharmacokinetic properties is generally based upon data that are derived from studies that employ small groups of young healthy animals, often of a single breed. In Part I of the series, we focused on the potential influence of disease processes, stress, pregnancy and lactation on drug pharmacokinetics. In this Part II of the series, we consider other covariates, such as gender, heritable traits, age, body composition, and circadian rhythms. The impact of these factors with respect to predicting the relationship between dose and drug exposure characteristics within an animal population is illustrated through the use of Monte Carlo simulations. Ultimately, an appreciation of these potential influences will improve the prediction of situations when dose adjustments may be appropriate.