Drug solubility classification in the dog
Article first published online: 13 MAR 2012
© Published 2012. This article is a U.S. Government work and is in the public domain in the USA
Journal of Veterinary Pharmacology and Therapeutics
Special Issue: Bioequivalence
Volume 35, Issue Supplement s1, pages 87–91, April 2012
How to Cite
MARTINEZ, M. N. and PAPICH, M. G. (2012), Drug solubility classification in the dog. Journal of Veterinary Pharmacology and Therapeutics, 35: 87–91. doi: 10.1111/j.1365-2885.2012.01373.x
- Issue published online: 13 MAR 2012
- Article first published online: 13 MAR 2012
- (Paper received 15 December 2011; accepted for publication 16 December 2011)
Martinez, M. N., Papich, M. G. Drug solubility classification in the dog. J. vet. Pharmacol. Therap. 35 (Suppl. 1), 87–91.
Similar to human drugs, oral drug delivery is a major route of drug administration in dogs. Therefore, it is important to consider how the physiological characteristics of the dog may influence the considerations that go into the classification of drug solubility. In this manuscript, we discuss the impact of body size vs. administered dose and gastric volume on the estimated gastric drug concentration that needs to be considered. However, when using a dose number (Do) paradigm, there are very few drugs for which the different methods of estimating gastric volume will alter the drug solubility classification. We also evaluate the range of pH values under which a solubility assessment should be generated and conclude that despite specific differences in the pH values of the gastrointestinal environment of people and dogs, the human pH criteria for evaluating drug solubility can be used when evaluating drug solubility of oral medications in dogs.