αCorrection added after online publication <8 November 2012>: <After submitting this manuscript, additional data became available from recent cattle flunixin pharmacokinetic studies in which bioavailabilities for flunixin after IM and SC administration were estimated to be 100%. Since the estimated WDIs for flunixin after extravascular administration routes were sensitive to bioavailability, readers should be mindful that the estimated WDI’s for extravascular administration routes of administration might be similar to that for the IV administration route.>
Use of population pharmacokinetic modeling and Monte Carlo simulation to capture individual animal variability in the prediction of flunixin withdrawal times in cattle
Article first published online: 19 JUN 2012
© 2012 Blackwell Publishing Ltd
Journal of Veterinary Pharmacology and Therapeutics
Volume 36, Issue 3, pages 248–257, June 2013
How to Cite
WU, H., BAYNES, R. E., LEAVENS, T., TELL, L. A. and RIVIERE, J. E. (2013), Use of population pharmacokinetic modeling and Monte Carlo simulation to capture individual animal variability in the prediction of flunixin withdrawal times in cattle. Journal of Veterinary Pharmacology and Therapeutics, 36: 248–257. doi: 10.1111/j.1365-2885.2012.01420.x
- Issue published online: 10 MAY 2013
- Article first published online: 19 JUN 2012
- (Paper received 24 February 2012; accepted for publication 12 May 2012)
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