The author D. Hennessy – Deceased.
Pharmacokinetics and bioequivalence in the pig of two ivermectin feed formulations
Article first published online: 8 AUG 2012
© 2012 John Wiley & Sons Ltd
Journal of Veterinary Pharmacology and Therapeutics
Volume 36, Issue 4, pages 350–357, August 2013
How to Cite
Pharmacokinetics and bioequivalence in the pig of two ivermectin feed formulations. J. vet. Pharmacol. Therap. 36, 350–357., , , , ,
- Issue published online: 4 JUL 2013
- Article first published online: 8 AUG 2012
- Manuscript Accepted: 7 JUL 2012
- Manuscript Received: 24 JAN 2012
Two premix products containing the endectocide ivermectin were compared for pharmacokinetic profiles and bioequivalence in young pigs. Test and reference articles were administered to individual pigs in-feed at 12-h intervals for a total of 14 doses. Plasma concentration–time profiles were compared after provision of the final doses of medicated feed, by which time steady-state concentrations of ivermectin had been achieved. The pharmacokinetic variables monitored were peak concentration (Cmax), area under the curve (AUC)0–last, elimination half-life of the terminal phase (T1/2 λz) and average steady-state concentration (Css), determined by noncompartmental analysis. Logarithmic transformation of the variables was carried out when appropriate. Analysis of data by the Classic Method yielded confidence intervals of 80.59–114.47 (for AUC0–last), 90.38–119.68 (for Cmax) and 84.70–111.96 (for Css). It was concluded that the two articles were bioequivalent for ivermectin.