Distribution of three major hepatitis C virus genotypes in Italy. A multicentre study of 49 5 patients with chronic hepatitis C
Article first published online: 18 DEC 2007
Journal of Viral Hepatitis
Volume 2, Issue 1, pages 33–38, January 1995
How to Cite
Pontisso, P., Ruvoletto, M. G., Nicoletti, M., Tisminetzky, S., Gerotto, M., Levrero, M., Artini, M., Baldi, M., Ballardini, G., Barbara, L., Bonetti, P., Brillanti, S., Casarin, C., Chemello, L., Costanzo, A., Mitri, M. S. D., Donada, C., Felaco, M. F., Frezza, M., Gaeta, G. B., Giostra, F., Iervese, T., Iacono, O. Lo., Milella, M., Monno, L., Negro, F., Piccinino, F., RUSSO, G., Vaccaro, A., Baralle, F. and Alberti, A. (1995), Distribution of three major hepatitis C virus genotypes in Italy. A multicentre study of 49 5 patients with chronic hepatitis C. Journal of Viral Hepatitis, 2: 33–38. doi: 10.1111/j.1365-2893.1995.tb00069.x
- Issue published online: 18 DEC 2007
- Article first published online: 18 DEC 2007
- Received 10 July 1994; accepted for publication 1 August 1994
- geographical distribution;
- HCV genotypes.
SUMMARY. Different genotypes of hepatitis C virus (HCV) have been shown to have distinct geographical distribution and to associate with variable clinical features. To evaluate their role in chronic hepatitis in Italian patients, we studied 495 consecutive cases with chronic hepatitis C seen in nine sentinel centres homo geneously distributed over Italy. HCV genotyping was carried out using a dot-blot hybridization assay with genotype-specific probes. Four hundred and eleven patients were viraemic and could be evaluated: 57% were found to be infected with HCV-1,31% with HCV-2, 8% with HCV-3. 1% showed mixed infection and 3% were ascribed to HCV-2b or HCV-4 by direct sequencing. Geographical distribution showed discrete territorial variations. A history of drug addiction was commoner in patients infected with HCV-3. There were no signifi cant differences in activity of liver disease among different HCV genotypes but the response to interferon therapy was reduced in patients infected with HCV-1 compared to HCV-2 or HCV-3.