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Treatment of hepatitis C


Janice Main, Faculty of Medicine, Imperial College, St Mary's Hospital, Praed Street, London W2 1NY, UK.


Summary.  The combination of pegylated interferon alpha and ribavirin has improved treatment success rates in patients with hepatitis C with sustained response rates of just over 50% overall and more than 70% for those with genotypes 2 and 3. This article reviews the use of combination therapy, contraindications, factors influencing response and describes approaches to specific patient groups.