The members of the steering group are given in the Appendix.
Does the clinical outcome of hepatitis C infection vary with the infecting hepatitis C virus type?
Article first published online: 21 AUG 2006
Journal of Viral Hepatitis
Volume 14, Issue 3, pages 213–220, March 2007
How to Cite
Harris, H. E., Eldridge, K. P., Harbour, S., Alexander, G., Teo, C.-G., Ramsay, M. E. and The HCV National Register Steering Group (2007), Does the clinical outcome of hepatitis C infection vary with the infecting hepatitis C virus type?. Journal of Viral Hepatitis, 14: 213–220. doi: 10.1111/j.1365-2893.2006.00795.x
- Issue published online: 21 AUG 2006
- Article first published online: 21 AUG 2006
- Received December 2005; accepted for publication March 2006
- hepatitis C;
- liver disease;
- natural history;
Summary. Whether differences in the natural history of hepatitis C virus (HCV) can be explained by differences in the infecting HCV type is unknown. The aim of this study was to investigate whether the HCV type might influence the clinical outcome of infection. Study serum samples were assembled from 749 individuals enrolled into the UK HCV National Register from which data on clinical outcomes were extracted. HCV-RNA-positive specimens were genotyped and HCV-RNA-negative specimens serotyped. Logistic regression analysis was used to investigate the independent effect of HCV type on viral clearance by comparing patients who were HCV RNA negative (n = 86) with those who were HCV RNA positive (n = 508). The same method was used to investigate whether HCV type was associated with histological stage of liver disease. The prevalence of HCV type 1 among those who cleared infection was 69% and among those who remained HCV RNA positive was 51%: Type 1 infections were more likely to be HCV RNA negative than non-1 types (OR 0.47, 95% CI 0.29–0.78, P = 0.003). Type 1 infections were also more likely to be associated with histological stage scores above the median when compared with non-1 types (OR 2.03, 95% CI 1.07–3.83, P = 0.03). In conclusion, HCV type 1 infection was more often HCV RNA negative, suggesting that spontaneous clearance may occur more commonly with this type. Among the RNA-positive infections, type 1 infection may be more aggressive than types 2/3.