1365-2893/asset/JVH_left.gif?v=1&s=b49347dbb27ed46f9f14bd61c3304105cb5a53be)
Hepatitis C virus infection: in vivo and in vitro models
Article first published online: 22 OCT 2007
DOI: 10.1111/j.1365-2893.2007.00918.x
Additional Information
How to Cite
Brass, V., Moradpour, D. and Blum, H. E. (2007), Hepatitis C virus infection: in vivo and in vitro models. Journal of Viral Hepatitis, 14: 64–67. doi: 10.1111/j.1365-2893.2007.00918.x
Publication History
- Issue published online: 22 OCT 2007
- Article first published online: 22 OCT 2007
- Received July 2007; accepted for publication August 2007
- Abstract
- Article
- References
- Cited By
Keywords:
- HCV replicons;
- HCV transgenic mice;
- HCV-like particles;
- primary hepatocytes;
- retroviral HCV pseudoparticles;
- tamarins;
- tupaias;
- urokinase plasminogen activator transgenic mice
Summary. Major advances in the understanding of the molecular biology of hepatitis C virus (HCV) have been made recently. While the chimpanzee is the only established animal model of HCV infection, several in vivo and in vitro models have been established that allow us to study various aspects of the viral life cycle. In particular, the replicon system and the production of recombinant infectious virions revolutionized the investigation of HCV-RNA replication and rendered all steps of the viral life cycle, including entry and release of viral particles, amenable to systematic analysis. In the following we will review the different in vivo and in vitro models of HCV infection.