Liver eosinophilic infiltrate is a significant finding in patients with chronic hepatitis C

Authors

  • G. Tarantino,

    1. Cattedra ed Unità Operativa di Gastroenterologia ed Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo
    Search for more papers by this author
    • *

      These authors contributed equally to this work.

  • D. Cabibi,

    1. Dipartimento di Patologia Umana, University of Palermo
    Search for more papers by this author
    • *

      These authors contributed equally to this work.

  • C. Cammà,

    1. Cattedra ed Unità Operativa di Gastroenterologia ed Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo
    Search for more papers by this author
  • N. Alessi,

    1. Cattedra ed Unità Operativa di Gastroenterologia ed Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo
    Search for more papers by this author
  • M. Donatelli,

    1. Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy
    Search for more papers by this author
  • S. Petta,

    1. Cattedra ed Unità Operativa di Gastroenterologia ed Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo
    Search for more papers by this author
  • A. Craxì,

    1. Cattedra ed Unità Operativa di Gastroenterologia ed Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo
    Search for more papers by this author
  • V. Di Marco

    1. Cattedra ed Unità Operativa di Gastroenterologia ed Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo
    Search for more papers by this author

Giuseppe Tarantino, MD, Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Piazza delle Cliniche, 2. 90127 Palermo, Italy. E-mail: giutar@alice.it

Abstract

Summary.  Eosinophilic infiltrate of liver tissue is described in primary cholestatic diseases, hepatic allograft rejection and drug-induced liver injury, but its significance and its implications in chronic hepatitis C are unknown. The aim of this study was to investigate the clinical significance of eosinophilic liver infiltrate in patients with chronic hepatitis C. We retrospectively evaluated 147 patients with chronic hepatitis C. The presence of eosinophilic infiltrate was investigated in liver biopsies, and a numeric count of eosinophilic leucocytes in every portal tract was assessed. An eosinophilic infiltrate of liver tissue (≥3 cells evaluated in the portal / periportal spaces) was observed in 46 patients (31%), and patients who consumed drugs had an odds ratio (OR) of 4.02 (95% CI: 1.62–9.96) to have an eosinophilic infiltrate in liver biopsy. By logistic regression analysis, the presence of steatosis was independently associated with eosinophilic infiltrate (OR 5.86; 95% CI: 2.46–13.96) and homeostasis model assessment-score (OR 1.18; 95% CI: 1.00–1.39). Logistic regression analysis also showed that fibrosis staging ≥ 2 by Scheuer score was associated with grading >1 by Scheuer score (OR 6.82; 95% CI 2.46–18.80) and eosinophilic infiltrate (OR 4.00; 95% CI 1.23–12.91). In conclusion, we observed that the eosinophilic infiltrate of liver tissue was significantly more frequent in patients who assumed drugs, and found a significant association between eosinophilic infiltrate, liver steatosis and liver fibrosis. These preliminary data could lead to a constant assumption of drugs as a co-factor of eosinophils-mediated liver injury in chronic hepatitis C.

Ancillary