Implication of normal liver enzymes in liver disease


Vincenza Calvaruso, Gastroenterologia & Epatologia, DIBIMIS, University of Palermo, Piazza delle Cliniche n.2, 90127 Palermo, Italy. E-mail:


Summary.  Chronic liver disease is usually asymptomatic until its late stages and also significant hepatic necroinflammation and fibrosis may be present in persistently normal ALT levels HBV, HCV carriers or similarly, in patients with nonalcoholic fatty liver disease. Given the large number of persons in the general population which may harbor a clinically significant liver disease behind the screen of normal alanine aminotransferase, more attention should be devoted to future research for alternative noninvasive markers of liver damage.