These authors contributed to this paper equally.
Comparison of entecavir and lamivudine in preventing hepatitis B reactivation in lymphoma patients during chemotherapy
Article first published online: 5 NOV 2010
© 2010 Blackwell Publishing Ltd
Journal of Viral Hepatitis
Volume 18, Issue 12, pages 877–883, December 2011
How to Cite
Li, H.-R., Huang, J.-J., Guo, H.-Q., Zhang, X., Xie, Y., Zhu, H.-L., Zhai, L.-Z., Pu, X.-X., Huang, Y., Guo, C.-C. and Lin, T.-Y. (2011), Comparison of entecavir and lamivudine in preventing hepatitis B reactivation in lymphoma patients during chemotherapy. Journal of Viral Hepatitis, 18: 877–883. doi: 10.1111/j.1365-2893.2010.01386.x
- Issue published online: 18 NOV 2011
- Article first published online: 5 NOV 2010
- Received March 2010; accepted for publication September 2010
- hepatitis B virus;
Summary. During chemotherapy for lymphoma, the administration of cytotoxic agents and rituximab often results in hepatitis B reactivation (incidence, 14–72%). This study was designed to compare the efficacy of entecavir and lamivudine in preventing hepatitis B reactivation in lymphoma patients. Between January 2007 and February 2009, patients treated in four hospitals in China were screened to identify those most appropriate for analysis. These patients received either entecavir or lamivudine during chemotherapy and for 6 months after completion of chemotherapy. A total of 34 patients received entecavir and 89 patients received lamivudine. Compared with the lamivudine group, the entecavir group had significantly lower rates of hepatitis (5.9 vs 27.0%, P = 0.007), hepatitis B reactivation (0 vs 12.4%, P = 0.024) and disruption of chemotherapy (5.9 vs 20.2%, P = 0.042). All patients with hepatitis B reactivation had B-cell non-Hodgkin’s lymphoma (stage III–IV). In lymphoma patients under chemotherapy treatment, entecavir is more effective than lamivudine in preventing hepatitis B reactivation. For patients with advanced stage disease, entecavir should be considered the primary preventive therapy.