Mechanisms of organophosphate and carbamate resistance in Culex quinquefasciatus from Saudi Arabia
Article first published online: 28 JUN 2008
Medical and Veterinary Entomology
Volume 4, Issue 3, pages 275–282, July 1990
How to Cite
HEMINGWAY, J., CALLAGHAN, A. and AMIN, A. M. (1990), Mechanisms of organophosphate and carbamate resistance in Culex quinquefasciatus from Saudi Arabia. Medical and Veterinary Entomology, 4: 275–282. doi: 10.1111/j.1365-2915.1990.tb00440.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Accepted 16 September 1989
- Culex quinquefasciatus;
- Cytochrome P450;
- Saudi Arabia
Abstract. Broad spectrum organophosphate resistance in Culex quinquefasciatus Say from Saudi Arabia is inherited as a semi-dominant characteristic. The resistance has a metabolic basis and confers cross-resistance against the carbamate propoxur. Organophosphate-selected strains contain two elevated esterases with the same electrophoretic mobilities as those in resistant Cx quinquefasciatus from Sri Lanka and a range of African locations. Alteration in the sensitivity of acetylcholinesterase to insecticide inhibition does not play a major role in resistance.
There was a significant increase in the amount of Cytochrome P450 in Cx quinquefasciatus lines selected with the pyrethroid permethrin or with the organophosphate pirimiphos-methyl, but no change in lines selected with five other organophosphates or propoxur, compared to the parental strain, which suggests that oxidases are involved in the P450 mediated resistance to both permethrin and pirimiphos-methyl.