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F-statistics of clonal diploids structured in numerous demes

Authors

  • THIERRY DE MEEÛS,

    Corresponding author
    1. Génétique et Evolution des Maladies Infectieuses, Equipe Evolution des Systèmes Symbiotiques, UMR 2724 CNRS-IRD, Centre IRD de Montpellier, 911 Avenue d’Agropolis, BP 64501, 34394 Montpellier cedex 5, France,
      Thierry De Meeûs, Fax: (33) 467 41 62 99; E-mail: demeeus@mpl.ird.fr
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  • FRANÇOIS BALLOUX

    1. Department of Genetics, Downing Street, University of Cambridge, Cambridge CB2 3EH, UK
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Thierry De Meeûs, Fax: (33) 467 41 62 99; E-mail: demeeus@mpl.ird.fr

Abstract

The expected apportionment of genetic diversity in diploid clonal organisms structured in numerous subpopulations is explored. Under the specific assumptions considered, corresponding, for instance, to clonal pathogens infecting a large number of hosts, the co-ancestry between individuals within subpopulations is the only nontrivial quantity. Thus the population structure can be fully described either by FST or FIS, as FST = –FIS/(1 − FIS). We show that, for most of the parameter space considered, including simulations where equilibrium is not reached and/or where homoplasy is high, the number of effective migrants is most accurately estimated as Nm = –(1 + FIS)/4FIS. We further propose a criterion to test for the absence of cryptic sexual reproduction based on the F-statistics FIS and FST, which is applied to three previously published empirical data sets.

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