Landscape genetics highlights the role of bank vole metapopulation dynamics in the epidemiology of Puumala hantavirus

Authors

  • E. GUIVIER,

    1. INRA, UMR CBGP (INRA/IRD/Cirad/Montpellier SupAgro), Campus international de Baillarguet, CS 30016, F-34988 Montferrier-sur-Lez Cedex, France
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  • M. GALAN,

    1. INRA, UMR CBGP (INRA/IRD/Cirad/Montpellier SupAgro), Campus international de Baillarguet, CS 30016, F-34988 Montferrier-sur-Lez Cedex, France
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  • Y. CHAVAL,

    1. INRA, UMR CBGP (INRA/IRD/Cirad/Montpellier SupAgro), Campus international de Baillarguet, CS 30016, F-34988 Montferrier-sur-Lez Cedex, France
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  • A. XUÉREB,

    1. INRA, UMR CBGP (INRA/IRD/Cirad/Montpellier SupAgro), Campus international de Baillarguet, CS 30016, F-34988 Montferrier-sur-Lez Cedex, France
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  • A. RIBAS SALVADOR,

    1. Laboratori de Parasitologia, Departament de Microbiologia i Parasitologia Sanitàries, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain
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  • M.-L. POULLE,

    1. Université de Reims Champagne Ardennes, Laboratoire de Parasitologie-Mycologie, EA 3800, UFR de Médecine, IFR 53, 51 rue Cognacq-Jay, 51096 Reims, France
    2. CERFE, 5 rue de la Héronnière, 08240 Boult-aux-Bois, France
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  • L. VOUTILAINEN,

    1. Finnish Forest Research Institute, POB 18, FI-01301, Vantaa, Finland
    2. Haartman Institute, FI-00014 University of Helsinki, Finland
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  • H. HENTTONEN,

    1. Finnish Forest Research Institute, POB 18, FI-01301, Vantaa, Finland
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  • N. CHARBONNEL,

    1. INRA, UMR CBGP (INRA/IRD/Cirad/Montpellier SupAgro), Campus international de Baillarguet, CS 30016, F-34988 Montferrier-sur-Lez Cedex, France
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  • J. F. COSSON

    1. INRA, UMR CBGP (INRA/IRD/Cirad/Montpellier SupAgro), Campus international de Baillarguet, CS 30016, F-34988 Montferrier-sur-Lez Cedex, France
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Jean-François Cosson, Fax: +33 (0)4 99 62 33 01; E-mail: cosson@supagro.inra.fr

Abstract

Rodent host dynamics and dispersal are thought to be critical for hantavirus epidemiology as they determine pathogen persistence and transmission within and between host populations. We used landscape genetics to investigate how the population dynamics of the bank vole Myodes glareolus, the host of Puumala hantavirus (PUUV), vary with forest fragmentation and influence PUUV epidemiology. We sampled vole populations within the Ardennes, a French PUUV endemic area. We inferred demographic features such as population size, isolation and migration with regard to landscape configuration. We next analysed the influence of M. glareolus population dynamics on PUUV spatial distribution. Our results revealed that the global metapopulation dynamics of bank voles were strongly shaped by landscape features, including suitable patch size and connectivity. Large effective size in forest might therefore contribute to the higher observed levels of PUUV prevalence. By contrast, populations from hedge networks highly suffered from genetic drift and appeared strongly isolated from all other populations. This might result in high probabilities of local extinction for both M. glareolus and PUUV. Besides, we detected signatures of asymmetric bank vole migration from forests to hedges. These movements were likely to sustain PUUV in fragmented landscapes. In conclusion, our study provided arguments in favour of source-sink dynamics shaping PUUV persistence and spread in heterogeneous, Western European temperate landscapes. It illustrated the potential contribution of landscape genetics to the understanding of the epidemiological processes occurring at this local scale.

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