These authors contributed equally to this work.
Evidence for genetic differentiation and variable recombination rates among Dutch populations of the opportunistic human pathogen Aspergillus fumigatus
Article first published online: 22 NOV 2011
© 2011 Blackwell Publishing Ltd
Volume 21, Issue 1, pages 57–70, January 2012
How to Cite
KLAASSEN, C. H. W., GIBBONS, J. G., FEDOROVA, N. D., MEIS, J. F. and ROKAS, A. (2012), Evidence for genetic differentiation and variable recombination rates among Dutch populations of the opportunistic human pathogen Aspergillus fumigatus. Molecular Ecology, 21: 57–70. doi: 10.1111/j.1365-294X.2011.05364.x
- Issue published online: 19 DEC 2011
- Article first published online: 22 NOV 2011
- Received 26 January 2011; revision received 28 September 2011; accepted 10 October 2011
Fig. S1 The effect of different clonal correction thresholds on the number of nonclonal genotypes identified from 255 Dutch A. fumigatus isolates.
Fig. S2 Structure and dapc analysis of the microsatellite marker (panels A and B), nonmicrosatellite marker (panels C and D) and full marker (panels E and F) data sets.
Fig. S3 The optimal number of populations K predicted by Structure analysis on data sets with varying levels of clonal correction.
Fig. S4 The distribution of alleles for each of the nine microsatellite markers and the one indel marker used in this study across the five A. fumigatus populations, as delineated by the Structure analysis.
Fig. S5 The distribution of alleles for each of the 10 sequence/PCR-typing markers used in this study across the five A. fumigatus populations, as delineated by the Structure analysis.
Fig. S6 Strength of association between markers and populations according to Cramér’s V statistic (Cramér 1999).
Fig. S7 Structure analysis is highly consistent across replicates.
Fig. S8 Geographical origin is not associated with genetic differentiation.
Table S1 The nomenclature, description, marker type, genomic location and origin of the 20 markers used in this study.
Table S2 The population assignment of the 156 nonclonally related clinical and environmental A. fumigatus genotypes from the Netherlands into five populations using the Structure and dapc approaches.
Table S3 The individual membership coefficients of the 156 nonclonally related clinical and environmental Dutch A. fumigatus genotypes from the Structure replicate used in this study against the average individual membership coefficients from the 100 Structure replicates calculated using the clumpp software.
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