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Innate immunity and the evolution of resistance to an emerging infectious disease in a wild bird

Authors

  • CAMILLE BONNEAUD,

    1. Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    2. Station d’Ecologie Expérimentale du CNRS (USR2936), 09200 Moulis, France
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  • SUSAN L. BALENGER,

    1. Department of Biological Sciences, Auburn University, Auburn, AL 36849, USA
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    • ¶Present address: Division of Genetics and Physiology, Department of Biology, University of Turku, Turku FIN-20014, Finland.

  • JIANGWEN ZHANG,

    1. Faculty of Arts and Sciences, Information Technology Research Computing, Harvard University, Cambridge, MA 02138, USA
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  • SCOTT V. EDWARDS,

    1. Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
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  • GEOFFREY E. HILL

    1. Department of Biological Sciences, Auburn University, Auburn, AL 36849, USA
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Camille Bonneaud, Fax: +33 5 61 96 08 51; E-mail: bonneaud@dr14.cnrs.fr

Abstract

Innate immunity is expected to play a primary role in conferring resistance to novel infectious diseases, but few studies have attempted to examine its role in the evolution of resistance to emerging pathogens in wild vertebrate populations. Here, we used experimental infections and cDNA microarrays to examine whether changes in the innate and/or acquired immune responses likely accompanied the emergence of resistance in house finches (Carpodacus mexicanus) in the eastern United States subject to a recent outbreak of conjunctivitis-causing bacterium (Mycoplasma gallisepticum—MG). Three days following experimental infection with MG, we observed differences in the splenic transcriptional responses between house finches from eastern U.S. populations, with a 12-year history of MG exposure, versus western U.S. populations, with no history of exposure to MG. In particular, western birds down-regulated gene expression, while eastern finches showed no expression change relative to controls. Studies involving poultry have shown that MG can manipulate host immunity, and our observations suggest that pathogen manipulation occurred only in finches from the western populations, outside the range of MG. Fourteen days after infection, eastern finches, but not western finches, up-regulated genes associated with acquired immunity (cell-mediated immunity) relative to controls. These observations suggest population differences in the temporal course of the response to infection with MG and imply that innate immune processes were targets of selection in response to MG in the eastern U.S. population.

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