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Sequential activation of dual promoters by different Sigma factors maintains spoVJ expression during successive developmental stages of Bacillus subtilis
Article first published online: 27 OCT 2006
DOI: 10.1111/j.1365-2958.1991.tb00783.x
1365-2958/asset/cover.gif?v=1&s=75254d9e3ae6a0f08085f34cc6e5bd65d8e3d52e "Molecular Microbiology")
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How to Cite
Foulger, D. and Errington, J. (1991), Sequential activation of dual promoters by different Sigma factors maintains spoVJ expression during successive developmental stages of Bacillus subtilis. Molecular Microbiology, 5: 1363–1373. doi: 10.1111/j.1365-2958.1991.tb00783.x
Publication History
- Issue published online: 27 OCT 2006
- Article first published online: 27 OCT 2006
- Received 22 November, 1990; revised 11 February, 1991.
- Abstract
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- Cited By
Summary
The spoVJ gene of Bacillus subtilis encodes a 36 k Da protein and is expressed only in the mother cell. spoVJ has an interesting pattern of regulation during sporulation because it is expressed from sequentially activated promoters. These promoters, designated P1 and P2, are under the control of different sigma factors, σEand σK, which become active at separate times during sporulation. Removal of promoter P1, leaving promoter P2 active, resulted in about a 30-minute delay in the formation of heat-resistant spores and demonstrated that the expression of spoVJ from both promoters is essential for normal sporulation. A comparison is made between the sequences of the spoVJ promoters and the promoters of other genes dependent upon σE and σk.