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Biomolecular Structure and Modelling Unit, Biochemistry Department, University College, Gower Street, London WC1E 6BT, UK.
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A pyruvate-stimulated adenylate cyclase has a sequence related to the fes/fps oncogenes and to eukaryotic cyclases
Article first published online: 27 OCT 2006
DOI: 10.1111/j.1365-2958.1991.tb01890.x
Additional Information
How to Cite
Peters, E. P., Wilderspin, A. F., Wood, S. P., Zvelebil, M. J. J. M., Sezer, O. and Danchin, A. (1991), A pyruvate-stimulated adenylate cyclase has a sequence related to the fes/fps oncogenes and to eukaryotic cyclases. Molecular Microbiology, 5: 1175–1181. doi: 10.1111/j.1365-2958.1991.tb01890.x
Publication History
- Issue published online: 27 OCT 2006
- Article first published online: 27 OCT 2006
- Received 5 September, 1990; revised 21 January, 1991.
- Abstract
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Summary
The pyruvate-stimulated adenylate cyclase from Brevibacterium liquefaciens produces up to 450μM cyclic AMP in the culture medium when the bacterium is grown on glucose and alanine. In this paper we report the cloning, expression and sequencing of the gene for this enzyme. Residues were identified, within the C-terminal domain, which are conserved in adenylate and guanylate cyclase sequences from eukaryotes and in the adenylate cyclase of the prokaryote Rhizobium meliloti. We have also identified a sequence of 30 residues near the N-terminus of the protein which is homologous to part of the regulatory domain of the cellular homologues of the oncogenes fes and fps; this sequence is also present in the avian Fujinami sarcoma virus fps gene.