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Expression of chitin synthase genes during yeast and hyphal growth phases of Candida albicans
Article first published online: 27 OCT 2006
DOI: 10.1111/j.1365-2958.1992.tb01494.x
1365-2958/asset/cover.gif?v=1&s=75254d9e3ae6a0f08085f34cc6e5bd65d8e3d52e "Molecular Microbiology")
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How to Cite
Chen-Wu, J. L., Zwicker, J., Bowen, A. R. and Robbins, P. W. (1992), Expression of chitin synthase genes during yeast and hyphal growth phases of Candida albicans. Molecular Microbiology, 6: 497–502. doi: 10.1111/j.1365-2958.1992.tb01494.x
Publication History
- Issue published online: 27 OCT 2006
- Article first published online: 27 OCT 2006
- Received 14 June, 1991: revised 10 September and 23 October, 1991; accepted 8 November, 1991.
- Abstract
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Summary
Chitin, the β1,4-linked polymer of N-acetylglucosamine, is a fibrous polysaccharide that in many yeasts helps to maintain the structure of the mother-bud junction and in filamentous fungi is often the major supporting component of the cell wall. We have previously described a Candida albicans chitin synthase, CHS1. The DNA and derived protein sequences of a second gene, CHS2, are presented and compared with previously published gene sequences. Northern blot analysis shows that strikingly different levels of synthase 1 and 2 expression occur during yeast and hyphal phases of Candida growth.