Copper uptake and resistance in bacteria
Article first published online: 27 OCT 2006
Volume 7, Issue 1, pages 1–5, January 1993
How to Cite
Cooksey, D. A. (1993), Copper uptake and resistance in bacteria. Molecular Microbiology, 7: 1–5. doi: 10.1111/j.1365-2958.1993.tb01091.x
- Issue published online: 27 OCT 2006
- Article first published online: 27 OCT 2006
- Received 20 June, 1992; revised and accepted 1 September, 1992.
Copper ions are essential for bacteria but can cause a number of toxic cellular effects if levels of free ions are not controlled. Investigations of copper-resistant bacteria have revealed several mechanisms, mostly plasmid-determined, that prevent cellular uptake of high levels of free copper ions. However, these studies have also revealed that bacteria apparently have efficient chromosomally encoded systems for uptake and management of trace levels of copper. This review will explore the relationship of copper uptake systems to resistance mechanisms and the possibility that copper resistance has evolved directly through modification of chromosomal copper uptake genes.