Translational frameshifting in the control of transposition in bacteria

Authors

  • Michael Chandler,

    Corresponding author
    1. Microbiologie et Génétique Moléculaire (UPR 9007), CNRS, 118 route de Narbonne, 31062 Toulouse Cedex, France.
    • *For correspondence. Tel. 61 33 59 82/61 33 59 87; Fax 61 33 58 86.

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  • Olivier Fayet

    1. Microbiologie et Génétique Moléculaire (UPR 9007), CNRS, 118 route de Narbonne, 31062 Toulouse Cedex, France.
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Summary

The expression of an increasing number of genes of both prokaryotic and eukaryotic origin has been shown to be regulated at the translational level by programmed (sequence-specific) ribosomal frame-shifting. Among these are the bacterial insertion sequences IS1 and two members of the widely distributed IS3-family, IS150 and IS911. Frameshifting provides a means of specifying several proteins with different functions using a minimum of genetic information. In this review, we survey present understanding of the way in which frameshifting is integrated into the overall control of transposition activity in these elements.

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