Translational frameshifting in the control of transposition in bacteria
Article first published online: 27 OCT 2006
Volume 7, Issue 4, pages 497–503, February 1993
How to Cite
Chandler, M. and Fayet, O. (1993), Translational frameshifting in the control of transposition in bacteria. Molecular Microbiology, 7: 497–503. doi: 10.1111/j.1365-2958.1993.tb01140.x
- Issue published online: 27 OCT 2006
- Article first published online: 27 OCT 2006
- Received 1 September, 1992; revised and accepted 8 October, 1992.
The expression of an increasing number of genes of both prokaryotic and eukaryotic origin has been shown to be regulated at the translational level by programmed (sequence-specific) ribosomal frame-shifting. Among these are the bacterial insertion sequences IS1 and two members of the widely distributed IS3-family, IS150 and IS911. Frameshifting provides a means of specifying several proteins with different functions using a minimum of genetic information. In this review, we survey present understanding of the way in which frameshifting is integrated into the overall control of transposition activity in these elements.