Regulation by Ca2+ in the Yersinia low-Ca2+ response

Authors

  • Susan C. Straley,

    Corresponding author
    1. Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky 40536-0084, USA.
    • *For correspondence. Tel. (606) 233 6538; Fax (606) 257 8994.

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  • Gregory V. Plano,

    1. Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky 40536-0084, USA.
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  • Elźbieta Skrzypek,

    1. Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky 40536-0084, USA.
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  • Pryce L. Haddix,

    1. Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky 40536-0084, USA.
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    • Department of Moleculaf Microbiology. Washington University School of Medicine, St. Louis. Missouri 63110. USA.

  • Kenneth A. Fields

    1. Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky 40536-0084, USA.
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Summary

The Yersinia low-Ca2+ response (LCR) is a regulatory response in which a set of plasmid-borne operons is transcriptionally regulated at 37°C in response to the presence or absence of mM concentrations of Ca2+. LCR-regulated operons encode secreted proteins with regulatory and virulence roles as well as non-secreted regulatory proteins and components of the secretion machinery. Downregulation by Ca2+ is imposed by a signalling cascade that includes secreted proteins and possibly also components of the secretion system and is hypothesized to act on membrane-bound inductive components. An important rote in LCR induction is played by LcrD, an inner-membrane protein with homologues in several virulence-associated and flagella assembly-related systems in diverse bacterial species. The mechanism of signal transduction in response to Ca2+ is not known, and the proteins that bind DNA to downregulate transcription have not been identified.

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