Why is transcription coupled to translation in bacteria?
Article first published online: 6 SEP 2004
Volume 54, Issue 3, pages 598–603, November 2004
How to Cite
Gowrishankar, J. and Harinarayanan, R. (2004), Why is transcription coupled to translation in bacteria?. Molecular Microbiology, 54: 598–603. doi: 10.1111/j.1365-2958.2004.04289.x
- Issue published online: 14 SEP 2004
- Article first published online: 6 SEP 2004
- Accepted 24 June, 2004.
Active mechanisms exist to prevent transcription that is uncoupled from translation in the protein-coding genes of bacteria, as exemplified by the phenomenon of nonsense polarity. Bacterial transcription–translation coupling may be viewed as one among several co-transcriptional processes, including those for mRNA processing and export in the eukaryotes, that operate in the various life forms to render the nascent transcript unavailable for formation of otherwise deleterious R-loops in the genome.