The role of nucleoid-associated proteins in the organization and compaction of bacterial chromatin
Article first published online: 24 MAR 2005
Volume 56, Issue 4, pages 858–870, May 2005
How to Cite
Dame, R. T. (2005), The role of nucleoid-associated proteins in the organization and compaction of bacterial chromatin. Molecular Microbiology, 56: 858–870. doi: 10.1111/j.1365-2958.2005.04598.x
- Issue published online: 7 APR 2005
- Article first published online: 24 MAR 2005
- Accepted 31 January, 2005.
The bacterial chromosomal DNA is folded into a compact structure called nucleoid. The shape and size of this ‘body’ is determined by a number of factors. Major players are DNA supercoiling, macromolecular crowding and architectural proteins, associated with the nucleoid, which are the topic of this MicroReview. Although many of these proteins were identified more than 25 years ago, the molecular mechanisms involved in the organization and compaction of DNA have only started to become clear in recent years. Many of these new insights can be attributed to the use of recently developed biophysical techniques.