The exosome: a macromolecular cage for controlled RNA degradation
Article first published online: 10 AUG 2006
Volume 61, Issue 6, pages 1372–1379, September 2006
How to Cite
Büttner, K., Wenig, K. and Hopfner, K.-P. (2006), The exosome: a macromolecular cage for controlled RNA degradation. Molecular Microbiology, 61: 1372–1379. doi: 10.1111/j.1365-2958.2006.05331.x
- Issue published online: 10 AUG 2006
- Article first published online: 10 AUG 2006
- Accepted 17 July, 2006.
The exosome, a large multisubunit complex with exoribonucleic activity, emerges as the central 3′ RNA degradation and processing factor in eukaryotes and archaea. But how are the many RNA substrates of the exosome degraded in a processive, yet controlled manner? Recent functional and structural progress shows that the exosome is a macromolecular cage, where the nuclease active sites are situated in a central processing chamber. A narrow entry pore controls access to the active sites in the processing chamber and prevents uncontrolled RNA decay. The emerging mechanism of exosome function suggests a strikingly parallel architectural concept to protein degradation by proteasomes.