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Genomic analysis of protein–DNA interactions in bacteria: insights into transcription and chromosome organization
Article first published online: 16 JUN 2007
DOI: 10.1111/j.1365-2958.2007.05781.x
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How to Cite
Wade, J. T., Struhl, K., Busby, S. J. W. and Grainger, D. C. (2007), Genomic analysis of protein–DNA interactions in bacteria: insights into transcription and chromosome organization. Molecular Microbiology, 65: 21–26. doi: 10.1111/j.1365-2958.2007.05781.x
Publication History
- Issue published online: 16 JUN 2007
- Article first published online: 16 JUN 2007
- Accepted 11 May, 2007.
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Summary
Chromatin immunoprecipitation (ChIP) is a powerful method to measure protein–DNA interactions in vivo, and it can be applied on a genomic scale with microarray technology (ChIP-chip). ChIP-chip has been used extensively to map DNA–protein interactions across eukaryotic chromosomes. Here we review recent applications of ChIP-chip to the study of bacteria, which provide important and unexpected insights into transcription and chromosome organization.