The staphylococcal respiratory response regulator SrrAB induces ica gene transcription and polysaccharide intercellular adhesin expression, protecting Staphylococcus aureus from neutrophil killing under anaerobic growth conditions

Authors

Errata

This article corrects:

  1. The staphylococcal respiratory response regulator SrrAB induces ica gene transcription and polysaccharide intercellular adhesin expression, protecting Staphylococcus aureus from neutrophil killing under anaerobic growth conditions Volume 65, Issue 5, 1276–1287, Article first published online: 3 August 2007

*E-mail gerd.doering@med.uni-tuebingen.de; Tel. (+49) 7071 298 2069; Fax (+49) 707129 3011.

In the article by M. Ulrich et al. (2007), on page 1285, the authors would like to correct the specificity of the antibody that was used.

The correction is as follows:

The antibody which was used in this work was raised to the deacetylated version of the exopolysaccharide PNAG as described by Maira-Litran et al. (Comparative opsonic and protective activities against Staphylococcus aureus of conjugate vaccines containing native or deacetylated staphylococcal poly-N-acetyl-β-(1-6)-glucosamine. Infect Immun 2005; 73: 6752-6762). These antibodies bind to both the native and deacetylated forms of PNAG, and have not been shown to bind to PIA, the term we used in our manuscript. PIA was characterized in Mack et al. (The intercellular adhesin involved in biofilm accumulation of Staphylococcus epidermidis is a linear beta-1, 6-linked glucosaminoglycan: purification and structural analysis. J Bacteriol 1996 Jan; 178(1): 175-83). Both exopolysaccharides are synthesized by proteins encoded in the ica operon but the PNAG and PIA described in these publications have some biochemical and biophysical differences.

Ancillary