SEARCH

SEARCH BY CITATION

References

  • Alderwick, L.J., Radmacher, E., Seidel, M., Gande, R., Hitchen, P.G., Morris, H.R., et al. (2005) Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan core. J Biol Chem 280: 3236232371.
  • Alderwick, L.J., Molle, V., Kremer, L., Cozzone, A.J., Dafforn, T.R., Besra, G.S., and Futterer, K. (2006) Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis. Proc Natl Acad Sci USA 103: 25582563.
  • Av-Gay, Y., and Everett, M. (2000) The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis. Trends Microbiol 8: 238244.
  • Av-Gay, Y., Jamil, S., and Drews, S.J. (1999) Expression and characterization of the Mycobacterium tuberculosis serine/threonine protein kinase PknB. Infect Immun 67: 56765682.
  • Bach, H., Wong, D., and Av-Gay, Y. (2009) Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA. Biochem J 420: 155160.
  • Barthe, P., Roumestand, C., Canova, M.J., Kremer, L., Hurard, C., Molle, V., and Cohen-Gonsaud, M. (2009) Dynamic and structural characterization of a bacterial FHA protein reveals a new autoinhibition mechanism. Structure 17: 568578.
  • Belanger, A.E., Besra, G.S., Ford, M.E., Mikusova, K., Belisle, J.T., Brennan, P.J., and Inamine, J.M. (1996) The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Proc Natl Acad Sci USA 93: 1191911924.
  • Bendt, A.K., Burkovski, A., Schaffer, S., Bott, M., Farwick, M., and Hermann, T. (2003) Towards a phosphoproteome map of Corynebacterium glutamicum. Proteomics 3: 16371646.
  • Bentley, S.D., Chater, K.F., Cerdeno-Tarraga, A.M., Challis, G.L., Thomson, N.R., James, K.D., et al. (2002) Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417: 141147.
  • Betts, J.C., Lukey, P.T., Robb, L.C., McAdam, R.A., and Duncan, K. (2002) Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol Microbiol 43: 717731.
  • Bhatt, A., Fujiwara, N., Bhatt, K., Gurcha, S.S., Kremer, L., Chen, B., et al. (2007a) Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice. Proc Natl Acad Sci USA 104: 51575162.
  • Bhatt, A., Molle, V., Besra, G.S., Jacobs, W.R., Jr, and Kremer, L. (2007b) The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development. Mol Microbiol 64: 14421454.
  • Boitel, B., Ortiz-Lombardia, M., Duran, R., Pompeo, F., Cole, S.T., Cervenansky, C., and Alzari, P.M. (2003) PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis. Mol Microbiol 49: 14931508.
  • Brennan, P.J., and Nikaido, H. (1995) The envelope of mycobacteria. Annu Rev Biochem 64: 2963.
  • Briken, V., Porcelli, S.A., Besra, G.S., and Kremer, L. (2004) Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response. Mol Microbiol 53: 391403.
  • Camacho, L.R., Constant, P., Raynaud, C., Laneelle, M.A., Triccas, J.A., Gicquel, B., et al. (2001) Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J Biol Chem 276: 1984519854.
  • Canova, M.J., Veyron-Churlet, R., Zanella-Cleon, I., Cohen-Gonsaud, M., Cozzone, A.J., Becchi, M., et al. (2008) The Mycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c. Proteomics 8: 521533.
  • Choi, K.H., Kremer, L., Besra, G.S., and Rock, C.O. (2000) Identification and substrate specificity of beta-ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J Biol Chem 275: 2820128207.
  • Cohen-Gonsaud, M., Barthe, P., Canova, M.J., Stagier-Simon, C., Kremer, L., Roumestand, C., and Molle, V. (2009) The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated by phosphorylation. J Biol Chem 284: 1929019300.
  • Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., et al. (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393: 537544.
  • Converse, S.E., Mougous, J.D., Leavell, M.D., Leary, J.A., Bertozzi, C.R., and Cox, J.S. (2003) MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence. Proc Natl Acad Sci USA 100: 61216126.
  • Cox, J.S., Chen, B., McNeil, M., and Jacobs, W.R., Jr (1999) Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 402: 7983.
  • Daffe, M., and Draper, P. (1998) The envelope layers of mycobacteria with reference to their pathogenicity. Adv Microb Physiol 39: 131203.
  • Dasgupta, A., Datta, P., Kundu, M., and Basu, J. (2006) The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division. Microbiology 152: 493504.
  • Domenech, P., Reed, M.B., and Barry, C.E., 3rd (2005) Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance. Infect Immun 73: 34923501.
  • Dubnau, E., Chan, J., Raynaud, C., Mohan, V.P., Laneelle, M.A., Yu, K., et al. (2000) Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice. Mol Microbiol 36: 630637.
  • Durocher, D., Smerdon, S.J., Yaffe, M.B., and Jackson, S.P. (2000a) The FHA domain in DNA repair and checkpoint signaling. Cold Spring Harb Symp Quant Biol 65: 423431.
  • Durocher, D., Taylor, I.A., Sarbassova, D., Haire, L.F., Westcott, S.L., Jackson, S.P., et al. (2000b) The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell 6: 11691182.
  • England, P., Wehenkel, A., Martins, S., Hoos, S., Andre-Leroux, G., Villarino, A., and Alzari, P.M. (2009) The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling. FEBS Lett 583: 301307.
  • Escuyer, V.E., Lety, M.A., Torrelles, J.B., Khoo, K.H., Tang, J.B., Rithner, C.D., et al. (2001) The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan. J Biol Chem 276: 4885448862.
  • Fernandez, P., Saint-Joanis, B., Barilone, N., Jackson, M., Gicquel, B., Cole, S.T., and Alzari, P.M. (2006) The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth. J Bacteriol 188: 77787784.
  • Fiuza, M., Canova, M.J., Zanella-Cleon, I., Becchi, M., Cozzone, A.J., Mateos, L.M., et al. (2008a) From the characterization of the four serine/threonine protein kinases (PknA/B/G/L) of Corynebacterium glutamicum toward the role of PknA and PknB in cell division. J Biol Chem 283: 1809918112.
  • Fiuza, M., Canova, M.J., Patin, D., Letek, M., Zanella-Cleon, I., Becchi, M., et al. (2008b) The MurC ligase essential for peptidoglycan biosynthesis is regulated by the serine/threonine protein kinase PknA in Corynebacterium glutamicum. J Biol Chem 283: 3655336563.
  • Flardh, K., and Buttner, M.J. (2009) Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium. Nat Rev Microbiol 7: 3649.
  • Glickman, M.S., and Jacobs, W.R., Jr (2001) Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline. Cell 104: 477485.
  • Glickman, M.S., Cox, J.S., and Jacobs, W.R., Jr (2000) A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis. Mol Cell 5: 717727.
  • Greenstein, A.E., Grundner, C., Echols, N., Gay, L.M., Lombana, T.N., Miecskowski, C.A., et al. (2005) Structure/function studies of Ser/Thr and Tyr protein phosphorylation in Mycobacterium tuberculosis. J Mol Microbiol Biotechnol 9: 167181.
  • Grundner, C., Gay, L.M., and Alber, T. (2005) Mycobacterium tuberculosis serine/threonine kinases PknB, PknD, PknE, and PknF phosphorylate multiple FHA domains. Protein Sci 14: 19181921.
  • Gupta, M., Sajid, A., Arora, G., Tandon, V., and Singh, Y. (2009) FHA domain containing protein Rv0019c and Polyketide-associated protein PapA5, from substrates of Serine/Threonine Protein Kinase PknB to interacting proteins of Mycobacterium tuberculosis. J Biol Chem 284: 3472334734.
  • Hanks, S.K., Quinn, A.M., and Hunter, T. (1988) The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241: 4252.
  • Heath, R.J., and Rock, C.O. (2002) The Claisen condensation in biology. Nat Prod Rep 19: 581596.
  • Hunter, R.L., Olsen, M., Jagannath, C., and Actor, J.K. (2006) Trehalose 6,6′-dimycolate and lipid in the pathogenesis of caseating granulomas of tuberculosis in mice. Am J Pathol 168: 12491261.
  • Kalinowski, J., Bathe, B., Bartels, D., Bischoff, N., Bott, M., Burkovski, A., et al. (2003) The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of l-aspartate-derived amino acids and vitamins. J Biotechnol 104: 525.
  • Kang, C.M., Abbott, D.W., Park, S.T., Dascher, C.C., Cantley, L.C., and Husson, R.N. (2005) The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev 19: 16921704.
  • Kang, C.M., Nyayapathy, S., Lee, J.Y., Suh, J.W., and Husson, R.N. (2008) Wag31, a homologue of the cell division protein DivIVA, regulates growth, morphology and polar cell wall synthesis in mycobacteria. Microbiology 154: 725735.
  • Keep, N.H., Ward, J.M., Cohen-Gonsaud, M., and Henderson, B. (2006) Wake up! Peptidoglycan lysis and bacterial non-growth states. Trends Microbiol 14: 271276.
  • Kremer, L., Baulard, A.R., and Besra, G.S. (2000) Genetics of mycolic acid biosynthesis. In Molecular Genetics of Mycobacteria. Hatfull, G.F., and Jacobs, W.R., Jr (eds). Washington, DC: ASM Press, pp. 173190.
  • Kremer, L., Dover, L.G., Carrere, S., Nampoothiri, K.M., Lesjean, S., Brown, A.K., et al. (2002) Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis. Biochem J 364: 423430.
  • Kumar, P., Kumar, D., Parikh, A., Rananaware, D., Gupta, M., Singh, Y., and Nandicoori, V.K. (2009) The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. J Biol Chem 284: 1109011099.
  • Lamichhane, G., Tyagi, S., and Bishai, W.R. (2005) Designer arrays for defined mutant analysis to detect genes essential for survival of Mycobacterium tuberculosis in mouse lungs. Infect Immun 73: 25332540.
  • Letek, M., Ordonez, E., Vaquera, J., Margolin, W., Flardh, K., Mateos, L.M., and Gil, J.A. (2008) DivIVA is required for polar growth in the MreB-lacking rod-shaped actinomycete Corynebacterium glutamicum. J Bacteriol 190: 32833292.
  • Molle, V., Kremer, L., Girard-Blanc, C., Besra, G.S., Cozzone, A.J., and Prost, J.F. (2003a) An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis. Biochemistry 42: 1530015309.
  • Molle, V., Fujita, M., Jensen, S.T., Eichenberger, P., Gonzalez-Pastor, J.E., Liu, J.S., and Losick, R. (2003b) The Spo0A regulon of Bacillus subtilis. Mol Microbiol 50: 16831701.
  • Molle, V., Brown, A.K., Besra, G.S., Cozzone, A.J., and Kremer, L. (2006) The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation. J Biol Chem 281: 3009430103.
  • Nanninga, N. (1991) Cell division and peptidoglycan assembly in Escherichia coli. Mol Microbiol 5: 791795.
  • Narayan, A., Sachdeva, P., Sharma, K., Saini, A.K., Tyagi, A.K., and Singh, Y. (2007) Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol Genomics 29: 6675.
  • Nguyen, L., Scherr, N., Gatfield, J., Walburger, A., Pieters, J., and Thompson, C.J. (2007) Antigen 84, an effector of pleiomorphism in Mycobacterium smegmatis. J Bacteriol 189: 78967910.
  • Niebisch, A., Kabus, A., Schultz, C., Weil, B., and Bott, M. (2006) Corynebacterial protein kinase G controls 2-oxoglutarate dehydrogenase activity via the phosphorylation status of the OdhI protein. J Biol Chem 281: 1230012307.
  • Nott, T.J., Kelly, G., Stach, L., Li, J., Westcott, S., Patel, D., et al. (2009) An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis. Sci Signal 2: ra12.
  • Ojha, A.K., Baughn, A.D., Sambandan, D., Hsu, T., Trivelli, X., Guerardel, Y., et al. (2008) Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria. Mol Microbiol 69: 164174.
  • Papavinasasundaram, K.G., Chan, B., Chung, J.H., Colston, M.J., Davis, E.O., and Av-Gay, Y. (2005) Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice. J Bacteriol 187: 57515760.
  • Parikh, A., Verma, S.K., Khan, S., Prakash, B., and Nandicoori, V.K. (2009) PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activity. J Mol Biol 386: 451464.
  • Perez, J., Garcia, R., Bach, H., De Waard, J.H., Jacobs, W.R., Jr, Av-Gay, Y., et al. (2006) Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD. Biochem Biophys Res Commun 348: 612.
  • Portevin, D., De Sousa-D'Auria, C., Houssin, C., Grimaldi, C., Chami, M., Daffe, M., and Guilhot, C. (2004) A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms. Proc Natl Acad Sci USA 101: 314319.
  • Reed, M.B., Domenech, P., Manca, C., Su, H., Barczak, A.K., Kreiswirth, B.N., et al. (2004) A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response. Nature 431: 8487.
  • Sala, C., Haouz, A., Saul, F.A., Miras, I., Rosenkrands, I., Alzari, P.M., and Cole, S.T. (2009) Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis. Mol Microbiol 71: 11021116.
  • Schaeffer, M.L., Agnihotri, G., Volker, C., Kallender, H., Brennan, P.J., and Lonsdale, J.T. (2001) Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB. J Biol Chem 276: 4702947037.
  • Schnappinger, D., Ehrt, S., Voskuil, M.I., Liu, Y., Mangan, J.A., Monahan, I.M., et al. (2003) Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment. J Exp Med 198: 693704.
  • Schultz, C., Niebisch, A., Schwaiger, A., Viets, U., Metzger, S., Bramkamp, M., and Bott, M. (2009) Genetic and biochemical analysis of the serine/threonine protein kinases PknA, PknB, PknG and PknL of Corynebacterium glutamicum: evidence for non-essentiality and for phosphorylation of OdhI and FtsZ by multiple kinases. Mol Microbiol 74: 724741.
  • Shah, I.M., Laaberki, M.H., Popham, D.L., and Dworkin, J. (2008) A eukaryotic-like Ser/Thr kinase signals bacteria to exit dormancy in response to peptidoglycan fragments. Cell 135: 486496.
  • Sharma, K., Chandra, H., Gupta, P.K., Pathak, M., Narayan, A., Meena, L.S., et al. (2004) PknH, a transmembrane Hank's type serine/threonine kinase from Mycobacterium tuberculosis is differentially expressed under stress conditions. FEMS Microbiol Lett 233: 107113.
  • Sharma, K., Gupta, M., Pathak, M., Gupta, N., Koul, A., Sarangi, S., et al. (2006a) Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo. J Bacteriol 188: 29362944.
  • Sharma, K., Gupta, M., Krupa, A., Srinivasan, N., and Singh, Y. (2006b) EmbR, a regulatory protein with ATPase activity, is a substrate of multiple serine/threonine kinases and phosphatase in Mycobacterium tuberculosis. FEBS J 273: 27112721.
  • Singh, A., Jain, S., Gupta, S., Das, T., and Tyagi, A.K. (2003) mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope. FEMS Microbiol Lett 227: 5363.
  • Singh, A., Gupta, R., Vishwakarma, R.A., Narayanan, P.R., Paramasivan, C.N., Ramanathan, V.D., and Tyagi, A.K. (2005) Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs. J Bacteriol 187: 41734186.
  • Stock, J.B., Ninfa, A.J., and Stock, A.M. (1989) Protein phosphorylation and regulation of adaptive responses in bacteria. Microbiol Rev 53: 450490.
  • Takayama, K., Wang, C., and Besra, G.S. (2005) Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin Microbiol Rev 18: 81101.
  • Telenti, A., Philipp, W.J., Sreevatsan, S., Bernasconi, C., Stockbauer, K.E., Wieles, B., et al. (1997) The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol. Nat Med 3: 567570.
  • Thakur, M., and Chakraborti, P.K. (2006) GTPase activity of mycobacterial FtsZ is impaired due to its transphosphorylation by the eukaryotic-type Ser/Thr kinase, PknA. J Biol Chem 281: 4010740113.
  • Thakur, M., and Chakraborti, P.K. (2008) Ability of PknA, a mycobacterial eukaryotic-type serine/threonine kinase, to transphosphorylate MurD, a ligase involved in the process of peptidoglycan biosynthesis. Biochem J 415: 2733.
  • Tropis, M., Meniche, X., Wolf, A., Gebhardt, H., Strelkov, S., Chami, M., et al. (2005) The crucial role of trehalose and structurally related oligosaccharides in the biosynthesis and transfer of mycolic acids in Corynebacterineae. J Biol Chem 280: 2657326585.
  • Umeyama, T., Lee, P.C., Ueda, K., and Horinouchi, S. (1999) An AfsK/AfsR system involved in the response of aerial mycelium formation to glucose in Streptomyces griseus. Microbiology 145 (Part 9): 22812292.
  • Veyron-Churlet, R., Molle, V., Taylor, R.C., Brown, A.K., Besra, G.S., Zanella-Cleon, I., et al. (2009) The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue. J Biol Chem 284: 64146424.
  • Vilcheze, C., Wang, F., Arai, M., Hazbon, M.H., Colangeli, R., Kremer, L., et al. (2006) Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nat Med 12: 10271029.
  • Villarino, A., Duran, R., Wehenkel, A., Fernandez, P., England, P., Brodin, P., et al. (2005) Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions. J Mol Biol 350: 953963.
  • Wehenkel, A., Bellinzoni, M., Grana, M., Duran, R., Villarino, A., Fernandez, P., et al. (2008) Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential. Biochim Biophys Acta 1784: 193202.
  • Wietzorrek, A., and Bibb, M. (1997) A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold. Mol Microbiol 25: 11811184.
  • Yuan, Y., Zhu, Y., Crane, D.D., and Barry, C.E., 3rd (1998) The effect of oxygenated mycolic acid composition on cell wall function and macrophage growth in Mycobacterium tuberculosis. Mol Microbiol 29: 14491458.
  • Zhang, N., Torrelles, J.B., McNeil, M.R., Escuyer, V.E., Khoo, K.H., Brennan, P.J., and Chatterjee, D. (2003) The Emb proteins of mycobacteria direct arabinosylation of lipoarabinomannan and arabinogalactan via an N-terminal recognition region and a C-terminal synthetic region. Mol Microbiol 50: 6976.
  • Zheng, X., Papavinasasundaram, K.G., and Av-Gay, Y. (2007) Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem Biophys Res Commun 355: 162168.