Bacterial protein acetylation: the dawning of a new age

Authors

  • Linda I. Hu,

    1. Department of Microbiology and Immunology, Loyola University Chicago, Stritch School of Medicine, 2160 S. First Avenue, Building 105, Maywood, IL 60153, USA.
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  • Bruno P. Lima,

    1. Department of Microbiology and Immunology, Loyola University Chicago, Stritch School of Medicine, 2160 S. First Avenue, Building 105, Maywood, IL 60153, USA.
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  • Alan J. Wolfe

    Corresponding author
      E-mail awolfe@lumc.edu; Tel. (+1) 708 216 5814; Fax (+1) 708 216 9574.
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E-mail awolfe@lumc.edu; Tel. (+1) 708 216 5814; Fax (+1) 708 216 9574.

Summary

Protein acetylation has historically been considered a predominantly eukaryotic phenomenon. Recent evidence, however, supports the hypothesis that acetylation broadly impacts bacterial physiology. To explore more rapidly the impact of protein acetylation in bacteria, microbiologists can benefit from the strong foundation established by investigators of protein acetylation in eukaryotes. To help advance this learning process, we will summarize the current understanding of protein acetylation in eukaryotes, discuss the emerging link between acetylation and metabolism and highlight the best-studied examples of protein acetylation in bacteria.

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