The dawning of a ‘Golden era’ in lantibiotic bioengineering
Article first published online: 11 OCT 2010
© 2010 Blackwell Publishing Ltd
Volume 78, Issue 5, pages 1077–1087, December 2010
How to Cite
Field, D., Hill, C., Cotter, P. D. and Ross, R. P. (2010), The dawning of a ‘Golden era’ in lantibiotic bioengineering. Molecular Microbiology, 78: 1077–1087. doi: 10.1111/j.1365-2958.2010.07406.x
- Issue published online: 21 NOV 2010
- Article first published online: 11 OCT 2010
- Accepted manuscript online: 28 SEP 2010 09:15PM EST
- Accepted 15 September, 2010.
There are many examples of highly modified antimicrobial peptides in nature, many of which are non-ribosomally synthesized. However, the bacterial lantibiotics are produced as gene-encoded pre-peptides that are subsequently modified by dedicated enzyme systems to form extraordinarily potent inhibitors. Consequently, they are much more amenable to bioengineering which could lead to the generation of a new arsenal of potent antimicrobials. However, although bioengineering of these compounds has been underway for at least two decades, significant progress has only been reported in recent years. This review charts these recent developments which suggest that we are entering a ‘Golden era’ of lantibiotic bioengineering.