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References

  • Appleyard, A.N., Choi, S., Read, D.M., Lightfoot, A., Boakes, S., Hoffmann, A., et al. (2009) Dissecting structural and functional diversity of the lantibiotic mersacidin. Chem Biol 16: 490498.
  • van den Berg van Saparoea, H.B., Bakkes, P.J., Moll, G.N., and Driessen, A.J. (2008) Distinct contributions of the nisin biosynthesis enzymes NisB and NisC and transporter NisT to prenisin production by Lactococcus lactis. Appl Environ Microbiol 74: 55415548.
  • Bierbaum, G., and Sahl, H.G. (2009) Lantibiotics: mode of action, biosynthesis and bioengineering. Curr Pharm Biotechnol 10: 218.
  • Bierbaum, G., Szekat, C., Josten, M., Heidrich, C., Kempter, C., Jung, G., and Sahl, H.G. (1996) Engineering of a novel thioether bridge and role of modified residues in the lantibiotic Pep5. Appl Environ Microbiol 62: 385392.
  • Boakes, S., Cortés, J., Appleyard, A.N., Rudd, B.A.M., and Dawson, M.J. (2009) Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system. Mol Microbiol 72: 11261136.
  • Bonelli, R.R., Schneider, T., Sahl, H.G., and Wiedemann, I. (2006) Insights into in vivo activities of lantibiotics from gallidermin and epidermin mode-of-action studies. Antimicrob Agents Chemother 50: 14491457.
  • Breukink, E., and de Kruijff, B. (2006) Lipid II as a target for antibiotics. Nat Rev Drug Discov 5: 321332.
  • Brotz, H., Bierbaum, G., Leopold, K., Reynolds, P.E., and Sahl, H.G. (1998) The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II. Antimicrob Agents Chemother 42: 154160.
  • Brumfitt, W., Salton, M.R., and Hamilton-Miller, J.M. (2002) Nisin, alone and combined with peptidoglycan-modulating antibiotics: activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. J Antimicrob Chemother 50: 731734.
  • Castiglione, F., Cavaletti, L., Losi, D., Lazzarini, A., Carrano, L., Feroggio, M., et al. (2007) A novel lantibiotic acting on bacterial cell wall synthesis produced by the uncommon actinomycete Planomonospora sp. Biochemistry 46: 58845895.
  • Castiglione, F., Lazzarini, A., Carrano, L., Corti, E., Ciciliato, I., Gastaldo, L., et al. (2008) Determining the structure and mode of action of microbisporicin, a potent lantibiotic active against multiresistant pathogens. Chem Biol 15: 2231.
  • Chatterjee, C., Paul, M., Xie, L., and van der Donk, W.A. (2005) Biosynthesis and mode of action of lantibiotics. Chem Rev 105: 633684.
  • Chatterjee, C., Patton, G.C., Cooper, L., Paul, M., and van der Donk, W.A. (2006) Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase. Chem Biol 13: 11091117.
  • Chen, P., Novak, J., Kirk, M., Barnes, S., Qi, F., and Caufield, P.W. (1998) Structure–activity study of the lantibiotic mutacin II from Streptococcus mutans T8 by a gene replacement strategy. Appl Environ Microbiol 64: 23352340.
  • Cooper, L.E., McClerren, A.L., Chary, A., and van der Donk, W.A. (2008) Structure–activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol 15: 10351045.
  • Cortés, J., Appleyard, A.N., and Dawson, M.J. (2009) Chapter 22: Whole cell generation of lantibiotic variants. In Methods in Enzymology. Hopwood, D.A. (ed.). San Diego: Academic Press, pp. 559574.
  • Cotter, P.D., Hill, C., and Ross, R.P. (2005a) Bacterial lantibiotics: strategies to improve therapeutic potential. Curr Protein Pept Sci 6: 6175.
  • Cotter, P.D., O'Connor, P.M., Draper L.A., Lawton, E.M., Deegan, L.H., Hill, C., and Ross, R.P. (2005b) Posttranslational conversion of l-serines to d-alanines is vital for optimal production and activity of the lantibiotic lacticin 3147. Proc Natl Acad Sci USA 102: 1858418589.
  • Cotter, P.D., Deegan, L.H., Lawton, E.M., Draper, L.A., O'Connor, P.M., Hill C., and Ross, R.P. (2006) Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design. Mol Microbiol 62: 735747.
  • Deegan, L., Suda, S., Lawton, E.M., Draper, L.A., Hugenholtz, F., Peschel, P., et al. (2010) Manipulation of charged residues within the two-peptide lantibiotic lacticin 3147. Microb Biotechnol 3: 222234.
  • Demel, R.A., Peelen, T., Siezen, R.J., De, B., and Kuipers, O.P. (1996) Nisin Z, mutant nisin Z and lacticin 481 interactions with anionic lipids correlate with antimicrobial activity. A monolayer study. Eur J Biochem 235: 267274.
  • Dodd, H.M., Horn, N., Hao, Z., and Gasson, M.J. (1992) A lactococcal expression system for engineered nisins. Appl Environ Microbiol 58: 36833693.
  • Dodd, H.M., Horn, N., and Gasson, M.J. (1995) A cassette vector for protein engineering the lantibiotic nisin. Gene 162: 163164.
  • Dodd, H.M., Horn, N., Giffard, C.J., and Gasson, M.J. (1996) A gene replacement strategy for engineering nisin. Microbiology 142 (Part 1): 4755.
  • Dorenbos, R., Stein, T., Kabel, J., Bruand, C., Bolhuis, A., Bron, S., et al. (2002) Thiol-disulfide oxidoreductases are essential for the production of the lantibiotic sublancin 168. J Biol Chem 277: 1668216688.
  • Field, D., Collins, B., Cotter, P.D., Hill, C., and Ross, R.P. (2007) A system for the random mutagenesis of the two-peptide lantibiotic lacticin 3147: analysis of mutants producing reduced antibacterial activities. J Mol Microbiol Biotechnol 13: 226234.
  • Field, D., Connor, P.M., Cotter, P.D., Hill, C., and Ross, R.P. (2008) The generation of nisin variants with enhanced activity against specific gram-positive pathogens. Mol Microbiol 69: 218230.
  • Field, D., Quigley, L., O'Connor, P.M., Rea M.C., Daly, K., Cotter, P.D., et al. (2010) Studies with bioengineered Nisin peptides highlight the broad-spectrum potency of Nisin V. Microb Biotechnol 3: 473486.
  • Foulston, L.C., and Bibb, M.J. (2010) Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes. Proc Natl Acad Sci USA 107: 1346113466.
  • Furgerson Ihnken, L.A., Chatterjee, C., and van der Donk, W.A. (2008) In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry 47: 73527363.
  • Galvez, A., Abriouel, H., Lopez, R.L., and Omar, N.B. (2007) Bacteriocin-based strategies for food biopreservation. Int J Food Microbiol 120: 5170.
  • Gálvez, A., Abriouel, H., Benomar, N., and Lucas, R. (2010) Microbial antagonists to food-borne pathogens and biocontrol. Curr Opin Biotechnol 21: 142148.
  • Galvin, M., Hill, C., and Ross, R.P. (1999) Lacticin 3147 displays activity in buffer against gram-positive bacterial pathogens which appear insensitive in standard plate assays. Lett Appl Microbiol 28: 355358.
  • Georgalaki, M.D., Van Den Berghe, E., Kritikos, D., Devreese, B., Beeumen, J.V., Kalantzopoulos, G., et al. (2002) Macedocin, a food-grade lantibiotic produced by Streptococcus macedonicus ACA-DC 198. Appl Environ Microbiol 68: 58915903.
  • González, B., Arca, P., Mayo, B., and Suárez, J.E. (1994) Detection, purification, and partial characterization of plantaricin C, a bacteriocin produced by a Lactobacillus plantarum strain of dairy origin. Appl Environ Microbiol 60: 21582163.
  • Goto, Y., Li, B., Claesen, J., Shi, Y., Bibb, M.J., and van der Donk, W.A. (2010) Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol 8: e1000339. doi:1000310.1001371/journal.pbio.1000339
  • Grasemann, H., Stehling, F., Brunar, H., Widmann, R., Laliberte, T.W., Molina, L., et al. (2007) Inhalation of Moli1901 in patients with cystic fibrosis. Chest 131: 14611466.
  • Haas, M., Kluskens, L.D., Kuipers, A., Rink, R., Nelemans, S.A., and Moll, G.N. (2008) Cyclic angiotensin analogs. Patent Application WO 018792A2 .
  • He, Z., Kisla, D., Zhang, L., Yuan, C., Green-Church, K.B., and Yousef, A.E. (2007) Isolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin. Appl Environ Microbiol 73: 168178.
  • Hoffmann, A., Pag, U., Wiedemann, I., and Sahl, H.G. (2002) Combination of antibiotic mechanisms in lantibiotics. Farmaco 57: 685691.
  • Islam, M.R., Shioya, K., Nagao, J., Nishie, M., Jikuya, H., Zendo, T., et al. (2009) Evaluation of essential and variable residues of nukacin ISK-1 by NNK scanning. Mol Microbiol 72: 14381447.
  • Karakas Sen, A., Narbad, A., Horn, N., Dodd, H.M., Parr, A.J., Colquhoun, I., and Gasson, M.J. (1999) Post-translational modification of nisin. The involvement of NisB in the dehydration process. Eur J Biochem 261: 524532.
  • Kluskens, L.D., Kuipers, A., Rink, R., de Boef, E., Fekken, S., Driessen, A.J., et al. (2005) Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin. Biochemistry 44: 1282712834.
  • Kluskens, L.D., Nelemans, S.A., Rink, R., de Vries, L., Meter-Arkema, A., Wang, Y., et al. (2009) Angiotensin-(1-7) with thioether bridge: an angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog. J Pharmacol Exp Ther 328: 849854.
  • Kodani, S., Hudson, M.E., Durrant, M.C., Buttner, M.J., Nodwell, J.R., and Willey, J.M. (2004) The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor. Proc Natl Acad Sci USA 101: 1144811453.
  • Kodani, S., Lodato, M.A., Durrant, M.C., Picart, F., and Willey, J.M. (2005) SapT, a lanthionine-containing peptide involved in aerial hyphae formation in the streptomycetes. Mol Microbiol 58: 13681380.
  • van Kraaij, C., Breukink, E., Rollema, H.S., Bongers, R.S., Kosters, H.A., de Kruijff, B., and Kuipers, O.P. (2000) Engineering a disulfide bond and free thiols in the lantibiotic nisin Z. Eur J Biochem 267: 901909.
  • Kuipers, O.P., Bierbaum, G., Ottenwalder, B., Dodd, H.M., Horn, N., Metzger, J., et al. (1996) Protein engineering of lantibiotics. Antonie Van Leeuwenhoek 69: 161169.
  • Kuipers, A., de Boef, E., Rink, R., Fekken, S., Kluskens, L.D., Driessen, A.J., et al. (2004) NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides. J Biol Chem 279: 2217622182.
  • Kuipers, A., Wierenga, J., Rink, R., Kluskens, L.D., Driessen, A.J., Kuipers, O.P., and Moll, G.N. (2006) Sec-mediated transport of posttranslationally dehydrated peptides in Lactococcus lactis. Appl Environ Microbiol 72: 76267633.
  • Kuipers, A., Meijer-Wierenga, J., Rink, R., Kluskens, L.D., and Moll, G.N. (2008) Mechanistic dissection of the enzyme complexes involved in biosynthesis of lacticin 3147 and nisin. Appl Environ Microbiol 74: 65916597.
  • Kuipers, A., Rink, R., and Moll, G.N. (2009) Translocation of a thioether-bridged azurin peptide fragment via the sec pathway in Lactococcus lactis. Appl Environ Microbiol 75: 38003802.
  • Kuipers, O.P., Rollema, H.S., Yap, W.M., Boot, H.J., Siezen, R.J., and de Vos, W.M. (1992) Engineering dehydrated amino acid residues in the antimicrobial peptide nisin. J Biol Chem 267: 2434024346.
  • Kupke, T., Kempter, C., Gnau, V., Jung, G., and Gotz, F. (1994) Mass spectroscopic analysis of a novel enzymatic reaction. Oxidative decarboxylation of the lantibiotic precursor peptide EpiA catalyzed by the flavoprotein EpiD. J Biol Chem 269: 56535659.
  • Lawton, E.M., Ross, R.P., Hill, C., and Cotter, P.D. (2007) Two-peptide lantibiotics: a medical perspective. Mini Rev Med Chem 7: 12361247.
  • Levengood, M.R., and van der Donk, W.A. (2008) Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett 18: 30253028.
  • Levengood, M.R., Knerr, P.J., Oman, T.J., and van der Donk, W.A. (2009a) In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids. J Am Chem Soc 131: 1202412025.
  • Levengood, M.R., Kerwood, C.C., Chatterjee, C., and van der Donk, W.A. (2009b) Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids. Chembiochem 10: 911919.
  • Li, B., and van der Donk, W.A. (2007) Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin. J Biol Chem 282: 2116921175.
  • Li, B., Yu, J.P., Brunzelle, J.S., Moll, G.N., van der Donk, W.A., and Nair, S.K. (2006) Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science 311: 14641467.
  • Lubelski, J., Overkamp, W., Kluskens, L.D., Moll, G.N., and Kuipers, O.P. (2008a) Influence of shifting positions of Ser, Thr, and Cys residues in prenisin on the efficiency of modification reactions and on the antimicrobial activities of the modified prepeptides. Appl Environ Microbiol 74: 46804685.
  • Lubelski, J., Rink, R., Khusainov, R., Moll, G.N., and Kuipers, O.P. (2008b) Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin. Cell Mol Life Sci 65: 455476.
  • McClerren, A.L., Cooper, L.E., Quan, C., Thomas, P.M., Kelleher, N.L., and van der Donk, W.A. (2006) Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci USA 103: 1724317248.
  • Majchrzykiewicz, J.A., Lubelski, J., Moll, G.N., Kuipers, A., Bijlsma, J.J.E., Kuipers, O.P., and Rink, R. (2010) Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence. Antimicrob Agents Chemother 54: 14981505.
  • Majer, F., Schmid, D.G., Altena, K., Bierbaum, G., and Kupke, T. (2002) The flavoprotein MrsD catalyzes the oxidative decarboxylation reaction involved in formation of the peptidoglycan biosynthesis inhibitor mersacidin. J Bacteriol 184: 12341243.
  • Meindl, K., Schmiederer, T., Schneider, K., Reicke, A., Butz, D., Keller, S., et al. (2010) Labyrinthopeptins: a new class of carbacyclic lantibiotics. Angew Chem Int Ed Engl 49: 11511154.
  • Meyer, C., Bierbaum, G., Heidrich, C., Reis, M., Suling, J., Iglesias-Wind, M.I., et al. (1995) Nucleotide sequence of the lantibiotic Pep5 biosynthetic gene cluster and functional analysis of PepP and PepC. Evidence for a role of PepC in thioether formation. Eur J Biochem 232: 478489.
  • Minamikawa, M., Kawai, Y., Inoue, N., and Yamazaki, K. (2005) Purification and characterization of warnericin RB4, anti-Alicyclobacillus bacteriocin, produced by Staphylococcus warneri RB4. Curr Microbiol 51: 2226.
  • Mota-Meira, M., LaPointe, G., Lacroix, C., and Lavoie, M.C. (2000) MICs of mutacin B-Ny266, nisin A, vancomycin, and oxacillin against bacterial pathogens. Antimicrob Agents Chemother 44: 2429.
  • Müller, W.M., Schmiederer, T., Ensle, P., and Süssmuth, R.D. (2010) In vitro biosynthesis of the prepeptide of type-III lantibiotic labyrinthopeptin A2 including formation of a C–C bond as a post-translational modification. Angew Chem Int Ed Engl 49: 24362440.
  • Niu, W.W., and Neu, H.C. (1991) Activity of mersacidin, a novel peptide, compared with that of vancomycin, teicoplanin, and daptomycin. Antimicrob Agents Chemother 35: 9981000.
  • O'Mahony, T., Rekhif, N., Cavadini, C., and Fitzgerald, G.F. (2001) The application of a fermented food ingredient containing ‘variacin’, a novel antimicrobial produced by Kocuria varians, to control the growth of Bacillus cereus in chilled dairy products. J Appl Microbiol 90: 106114.
  • Oman, T.J., and van der Donk, W.A. (2009) Insights into the mode of action of the two-peptide lantibiotic haloduracin. ACS Chem Biol 4: 865874.
  • Ottenwalder, B., Kupke, T., Brecht, S., Gnau, V., Metzger, J., Jung, G., and Gotz, F. (1995) Isolation and characterization of genetically engineered gallidermin and epidermin analogs. Appl Environ Microbiol 61: 38943903.
  • Patton, G.C., Paul, M., Cooper, L.E., Chatterjee, C., and van der Donk, W.A. (2008) The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry 47: 73427351.
  • Peschel, A., Ottenwälder, B., and Götz, F. (1996) Inducible production and cellular location of the epidermin biosynthetic enzyme EpiB using an improved staphylococcal expression system. FEMS Microbiol Lett 137: 279284.
  • Piper, C., Cotter, P.D., Ross, R.P., and Hill, C. (2009a) Discovery of medically significant lantibiotics. Curr Drug Discov Technol 6: 118.
  • Piper, C., Draper, L.A., Cotter, P.D., Ross, R.P., and Hill, C. (2009b) A comparison of the activities of lacticin 3147 and nisin against drug-resistant Staphylococcus aureus and Enterococcus species. J Antimicrob Chemother 63: 546551.
  • Rink, R., Wierenga, J., Kuipers, A., Kluskens, L.D., Driessen, A.J., Kuipers, O.P., and Moll, G.N. (2007a) Production of dehydroamino acid-containing peptides by Lactococcus lactis. Appl Environ Microbiol 73: 17921796.
  • Rink, R., Wierenga, J., Kuipers, A., Kluskens, L.D., Driessen, A.J., Kuipers, O.P., and Moll, G.N. (2007b) Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation. Appl Environ Microbiol 73: 58095816.
  • Rink, R., Arkema-Meter, A., Baudoin, I., Post, E., Kuipers, A., Nelemans, S.A., et al. (2010) To protect peptide pharmaceuticals against peptidases. J Pharmacol Toxicol Methods 61: 210218.
  • Rollema, H.S., Kuipers, O.P., Both, P., de Vos, W.M., and Siezen, R.J. (1995) Improvement of solubility and stability of the antimicrobial peptide nisin by protein engineering. Appl Environ Microbiol 61: 28732878.
  • Ross, R.P., Morgan, S., and Hill, C. (2002) Preservation and fermentation: past, present and future. Int J Food Microbiol 79: 316.
  • Sahl, H., and Bierbaum, G. (2008) Multiple activities of natural agents such as defensins and bacteriocins suggest a change in strategy when developing new antimicrobials. Microbe 3: 467473.
  • Sahl, H., Jack, R., and Bierbaum, G. (1995) Biosynthesis and biological activities of lantibiotics with unique post-translational modifications. Eur J Biochem 230: 827853.
  • Schmitz, S., Hoffmann, A., Szekat, C., Rudd, B., and Bierbaum, G. (2006) The lantibiotic mersacidin is an autoinducing peptide. Appl Environ Microbiol 72: 72707277.
  • Siegers, K., Heinzmann, S., and Entian, K.D. (1996) Biosynthesis of lantibiotic nisin. Posttranslational modification of its prepeptide occurs at a multimeric membrane-associated lanthionine synthetase complex. J Biol Chem 271: 1229412301.
  • Sobrino-Lopez, A., and Martin-Belloso, O. (2008) Use of nisin and other bacteriocins for preservation of dairy products. Int Dairy J 18: 329343.
  • Somma, S., Merati, W., and Parenti, F. (1977) Gardimycin, a new antibiotic inhibiting peptidoglycan synthesis. Antimicrob Agents Chemother 11: 396401.
  • Szekat, C., Jack, R.W., Skutlarek, D., Farber, H., and Bierbaum, G. (2003) Construction of an expression system for site-directed mutagenesis of the lantibiotic mersacidin. Appl Environ Microbiol 69: 37773783.
  • Tagg, J.R. (2004) Prevention of streptococcal pharyngitis by anti-Streptococcus pyogenes bacteriocin-like inhibitory substances (BLIS) produced by Streptococcus salivarius. Indian J Med Res 119 (Suppl.): 1316.
  • Ueda, K., Oinuma, K.-I., Ikeda, G., Hosono, K., Ohnishi, Y., Horinouchi, S., and Beppu, T. (2002) AmfS, an extracellular peptidic morphogen in Streptomyces griseus. J Bacteriol 184: 14881492.
  • Uguen, P., Le, J.P., and Dufour, A. (2000) Lantibiotic biosynthesis: interactions between prelacticin 481 and its putative modification enzyme, LctM. J Bacteriol 182: 52625266.
  • Van Kraaij, C., Breukink, E., Rollema, H.S., Siezen, R.J., Demel, R.A., De, B., and Kuipers, O.P. (1997) Influence of charge differences in the C-terminal part of nisin on antimicrobial activity and signaling capacity. Eur J Biochem 247: 114120.
  • Wescombe, P.A., Heng, N.C.K., Burton, J.P., Chilcott, C.N., and Tagg, J.R. (2009) Streptococcal bacteriocins and the case for Streptococcus salivarius as model oral probiotics. Future Microbiol 4: 819835.
  • Wiedemann, I., Breukink, E., van Kraaij, C., Kuipers, O.P., Bierbaum, G., de Kruijff, B., and Sahl, H.G. (2001) Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. J Biol Chem 276: 17721779.
  • Wiedemann, I., Bottiger, T., Bonelli, R.R., Wiese, A., Hagge, S.O., Gutsmann, T., et al. (2006a) The mode of action of the lantibiotic lacticin 3147 – a complex mechanism involving specific interaction of two peptides and the cell wall precursor lipid II. Mol Microbiol 61: 285296.
  • Wiedemann, I., Bottiger, T., Bonelli, R.R., Schneider, T., Sahl, H.G., and Martinez, B. (2006b) Lipid II-based antimicrobial activity of the lantibiotic plantaricin C. Appl Environ Microbiol 72: 28092814.
  • Willey, J.M., and van der Donk, W.A. (2007) Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol 61: 477501.
  • Xie, L., Chatterjee, C., Balsara, R., Okeley, N.M., and van der Donk, W.A. (2002) Heterologous expression and purification of SpaB involved in subtilin biosynthesis. Biochem Biophys Res Commun 295: 952957.
  • Xie, L., Miller, L.M., Chatterjee, C., Averin, O., Kelleher, N.L., and van der Donk, W.A. (2004) Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science 303: 679681.
  • Yuan, J., Zhang, Z.Z., Chen, X.Z., Yang, W., and Huan, L.D. (2004) Site-directed mutagenesis of the hinge region of nisinZ and properties of nisinZ mutants. Appl Microbiol Biotechnol 64: 806815.
  • Zimmermann, N., and Jung, G. (1997) The three-dimensional solution structure of the lantibiotic murein-biosynthesis-inhibitor actagardine determined by NMR. Eur J Biochem 246: 809819.